Fischer-Suárez Natalia, Fernández-Alonso Ana M, Herrera-Muñoz Alejandra, Chedraui Peter, Pérez-López Faustino R
a Department of Obstetrics and Gynecology , Hospital Torrecárdenas , Almeria , Spain.
b Institute of Biomedicine, Research Area for Women's Health, Facultad de Ciencias Médicas, Universidad Católica de Santiago de Guayaquil , Guayaquil , Ecuador.
Gynecol Endocrinol. 2016 Sep;32(9):777-781. doi: 10.1080/09513590.2016.1177011. Epub 2016 Apr 26.
To measure 25-hydroxyvitamin D [25(OH)D] and C-reactive protein (CRP) serum levels in singleton gestations complicated with threatened preterm labour (TPL, n = 59) and compare to normal controls matched for gestational age (n = 64). Cases were treated after blood sample according to institutional protocol. Also, analyte levels were compared among cases according to the outcome.
Mean serum 25(OH)D levels were similar between cases and controls, with median white blood cell count and CRP levels found significantly higher in TPL cases. Women with TPL delivering preterm displayed shorter mean cervical lengths along with higher CRP and lower 25(OH)D serum levels when compared to those delivering at term. Two multiple linear regression models were constructed to analyse factors related to gestational age at delivery (pooled analysis and only those with TPL). In both models, gestational age positively correlated to cervical length and inversely to CRP levels; whereas, in the TPL model, only 25(OH)D levels correlated positively.
Women complicated with TPL showed similar serum 25(OH)D yet higher CRP levels as compared to controls. TPL cases delivering preterm displayed lower 25(OH)D and higher CRP correlated levels.
检测单胎妊娠合并先兆早产（TPL，n = 59）孕妇血清中25-羟维生素D [25(OH)D] 和C反应蛋白（CRP）水平，并与孕周匹配的正常对照组（n = 64）进行比较。病例在采集血样后根据机构方案进行治疗。此外，根据结局对病例组的分析物水平进行比较。
病例组和对照组的血清25(OH)D平均水平相似，但TPL病例的白细胞计数中位数和CRP水平显著更高。与足月分娩的女性相比，早产的TPL女性的平均宫颈长度更短，CRP水平更高，25(OH)D血清水平更低。构建了两个多元线性回归模型来分析与分娩孕周相关的因素（汇总分析以及仅TPL病例）。在两个模型中，孕周与宫颈长度呈正相关，与CRP水平呈负相关；然而，在TPL模型中，只有25(OH)D水平呈正相关。
与对照组相比，合并TPL的女性血清25(OH)D水平相似，但CRP水平更高。早产的TPL病例25(OH)D水平较低，CRP水平较高且两者相关。
