Blunt S M, Clayton R N, Butt W R
Clin Endocrinol (Oxf). 1986 Nov;25(5):589-96. doi: 10.1111/j.1365-2265.1986.tb03613.x.
Serum concentrations of LHRH and the subsequent LH responses were compared following s.c. injections of 20 micrograms LHRH into the upper arm and the lower abdominal wall, in 9 hypogonadal women responsive to pulsatile LHRH therapy. Tests were carried out at the two sites in random order. Peak LHRH concentrations were reached by 5 min after upper arm and by 20 min after lower abdominal wall injections, the maximum concentrations being significantly greater following injections into the former. There was no increase in LH until 10 min and then maximum concentrations were reached at 30 min following injection into both sites. There was no significant correlation between the LHRH increments and the LH response but there was a negative correlation between the Ponderal Index of the patients and the LHRH increments following injections into the lower abdominal wall only. There was no significant overall difference between the LH increments related to the site of injection, but the order of injections affected the responses. When upper arm injections were given first the LH responses were significantly greater, but when lower abdominal wall was injected first the subsequent responses to upper arm injections were impaired. A possible reason for this is that the absorption from the lower abdominal wall was delayed so prolonging the exposure of the pituitary gonadotrophs to LHRH, resulting in pituitary desensitization at the time of the second test.
对9名对脉冲式促性腺激素释放激素（LHRH）疗法有反应的性腺功能减退女性，在上臂和下腹壁皮下注射20微克LHRH后，比较血清LHRH浓度及随后的促黄体生成素（LH）反应。在这两个部位按随机顺序进行测试。上臂注射后5分钟达到LHRH峰值浓度，下腹壁注射后20分钟达到峰值浓度，在前一部位注射后的最大浓度显著更高。直到注射后10分钟LH才升高，然后在两个部位注射后30分钟达到最大浓度。LHRH增量与LH反应之间无显著相关性，但仅在下腹壁注射后，患者的体重指数与LHRH增量之间呈负相关。与注射部位相关的LH增量之间无显著总体差异，但注射顺序影响反应。当先进行上臂注射时，LH反应显著更大，但当先进行下腹壁注射时，随后对上臂注射的反应受损。对此的一个可能原因是下腹壁的吸收延迟，从而延长了垂体促性腺细胞对LHRH的暴露时间，导致在第二次测试时垂体脱敏。
