一种直接构建 2-脱氧-β-连接糖的改进方法：在寡糖合成中的应用。
An Improved Approach to the Direct Construction of 2-Deoxy-β-Linked Sugars: Applications to Oligosaccharide Synthesis.
机构信息
Department Department of Chemistry, Tufts University, 62 Talbot Ave., Medford, MA, 02155, USA.
出版信息
Chemistry. 2018 May 28;24(30):7610-7614. doi: 10.1002/chem.201800736. Epub 2018 May 2.
Abstract
A next-generation reagent-controlled approach for the synthesis of 2,6-dideoxy and 2,3,6-trideoxy sugar donors in good yield and high β-selectivity is reported. The use of p-toluenesulfonyl chloride and potassium hexamethyldisilazide (KHMDS) greatly simplifies deoxy-sugar glycoside construction, and can be used for gram-scale glycosylation reactions. The development of this approach and its application to the construction of β-linked deoxy-sugar oligosaccharides are described.
摘要
报道了一种用于合成 2,6-二脱氧和 2,3,6-三脱氧糖供体的新一代试剂控制方法，该方法具有高产率和高β选择性。使用对甲苯磺酰氯和六甲基二硅基叠氮化钾（KHMDS）极大地简化了脱氧糖糖苷的构建，并且可以用于克级糖基化反应。描述了这种方法的发展及其在β-连接的脱氧糖寡糖构建中的应用。
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