Department of Neurology, Kyung Hee University Medical Center, Seoul, Korea.
Department of Mechanical and Aerospace Engineering, Seoul National University, Seoul, Korea.
J Korean Med Sci. 2018 Mar 26;33(13):e96. doi: 10.3346/jkms.2018.33.e96.
Quantitative susceptibility mapping (QSM) has been used to measure iron accumulation in the deep nuclei of patients with Parkinson's disease (PD). This study examined the relationship between non-motor symptoms (NMSs) and iron accumulation in the deep nuclei of patients with PD.
The QSM data were acquired from 3-Tesla magnetic resonance imaging (MRI) in 29 patients with early PD and 19 normal controls. The Korean version of the NMS scale (K-NMSS) was used for evaluation of NMSs in patients. The patients were divided into high NMS and low NMS groups. The region-of-interest analyses were performed in the following deep nuclei: red nucleus, substantia nigra pars compacta, substantia nigra pars reticulata, dentate nucleus, globus pallidus, putamen, and head of the caudate nucleus.
Thirteen patients had high NMS scores (total K-NMSS score, mean = 32.1), and 16 had low NMS scores (10.6). The QSM values in the deep were not different among the patients with high NMS scores, low NMS scores, and controls. The QSM values were not correlated linearly with K-NMSS total score after adjusting the age at acquisition of brain MRI.
The study demonstrated that the NMS burdens are not associated with iron accumulation in the deep nuclei of patients with PD. These results suggest that future neuroimaging studies on the pathology of NMSs in PD should use more specific and detailed clinical tools and recruit PD patients with severe NMSs.
定量磁敏感图（QSM）已被用于测量帕金森病（PD）患者深部核团的铁积累。本研究探讨了 PD 患者深部核团铁积累与非运动症状（NMSs）之间的关系。
从 29 例早期 PD 患者和 19 例正常对照者的 3T 磁共振成像（MRI）中获取 QSM 数据。使用韩国非运动症状量表（K-NMSS）评估患者的 NMSs。将患者分为高 NMS 组和低 NMS 组。对以下深部核团进行感兴趣区分析：红核、黑质致密部、黑质网状部、齿状核、苍白球、壳核和尾状核头部。
13 例患者的 NMS 评分较高（K-NMSS 总分，平均值=32.1），16 例患者的 NMS 评分较低（10.6）。高 NMS 评分患者、低 NMS 评分患者和对照组之间深部 QSM 值无差异。经 MRI 采集时年龄校正后，QSM 值与 K-NMSS 总分之间无线性相关。
本研究表明，NMS 负担与 PD 患者深部核团的铁积累无关。这些结果提示，未来有关 PD 中 NMS 病理的神经影像学研究应使用更特异和详细的临床工具，并招募 NMS 严重的 PD 患者。
