College of Medical Technology, Shanghai University of Medicine & Health Sciences, 279 Zhouzhu Road, Shanghai 201318, China.
Cytokine. 2018 Aug;108:57-59. doi: 10.1016/j.cyto.2018.03.018. Epub 2018 Mar 22.
The relationship between the interleukin (IL)-11 levels and semen quality of infertile males remains unknown. In this study, 120 semen samples from 60 normozoospermic volunteers and 60 infertile males were examined. The semen pH of the normozoospermic group was not significantly different from that of the infertile group. The semen volume, semen density, forward movement percentage, activity, survival rate and normal morphology rate of the sperm of the infertile group were significantly lower than those of the normozoospermic group. The semen IL-11 levels of the infertile group were significantly lower than those of the normozoospermic group. In the infertile group, semen IL-11 levels were positively correlated with sperm motility, vitality, survival rate and normal sperm morphology rate and negatively correlated with IL-17 and IL-18 levels. Therefore, semen IL-11 levels could be used as an index of male infertility.
白细胞介素 (IL)-11 水平与男性不育症精液质量之间的关系尚不清楚。本研究共检测了 60 名正常生育志愿者和 60 名不育男性的 120 份精液样本。正常生育组的精液 pH 值与不育组无显著差异。不育组的精液量、精液密度、前向运动百分比、活力、存活率和正常形态率均明显低于正常生育组。不育组的精液白细胞介素-11 (IL-11) 水平明显低于正常生育组。在不育组中，精液 IL-11 水平与精子活力、活力、存活率和正常精子形态率呈正相关，与白细胞介素-17 (IL-17) 和白细胞介素-18 (IL-18) 水平呈负相关。因此，精液 IL-11 水平可作为男性不育症的一个指标。
