Reproductive Center, The 2nd Affiliated Hospital of Wenzhou Medical University, 109 College Road West, Wenzhou, 325027, China.
Reproductive Center, The 2nd Affiliated Hospital of Wenzhou Medical University, 109 College Road West, Wenzhou, 325027, China.
J Reprod Immunol. 2017 Sep;123:1-2. doi: 10.1016/j.jri.2017.08.007. Epub 2017 Aug 24.
The effects of diabetes mellitus (DM) on the quality and cytokine levels of human semen remain unknown. Sixty semen samples from 30 normal volunteers and 30 DM patients were assayed. The percentage of sperm progressive motility, sperm vitality, sperm survival rate, the rate of normal sperm morphology, semen volume, and semen pH and density of DM males were significantly lower than those of normal males (p<0.05). Moreover, semen interleukin (IL)-17 and IL-18 levels in DM males were significantly higher than those in normal males (p<0.05) and were positively correlated with blood glucose level and sperm DNA fragmentation index. DM increased blood glucose levels, consequently inducing the abnormal expression of IL-17 and IL-18. The abnormal expression of these cytokines in semen decreased semen quality and might lead to male infertility.
糖尿病（DM）对人精液质量和细胞因子水平的影响尚不清楚。检测了 30 名正常志愿者和 30 名 DM 患者的 60 份精液样本。DM 男性的精子前向运动百分比、精子活力、精子存活率、正常精子形态率、精液量、精液 pH 值和密度均明显低于正常男性（p<0.05）。此外，DM 男性的精液白细胞介素（IL）-17 和 IL-18 水平明显高于正常男性（p<0.05），且与血糖水平和精子 DNA 碎片化指数呈正相关。DM 增加血糖水平，进而导致 IL-17 和 IL-18 的异常表达。这些细胞因子在精液中的异常表达降低了精液质量，可能导致男性不育。
