Univ. Grenoble Alpes, F-38000 Grenoble, France; Inserm, U1216, Grenoble Institut des Neurosciences, F-38000 Grenoble, France.
Univ. Grenoble Alpes, F-38000 Grenoble, France; Laboratoire InterUniversitaire de Psychologie, EA 4145, BP 1104, F-73011 Chambéry, France; Université de Savoie, BP 1104, F-73011 Chambéry, France.
Clin Neurophysiol. 2018 May;129(5):1041-1046. doi: 10.1016/j.clinph.2018.02.127. Epub 2018 Mar 10.
In the context of the first clinical trial of vagus nerve stimulation (VNS) in Crohn's disease (CD), our main objective was to quantify the acute and chronic effects of VNS on brain activity in CD patients.
We measured the electroencephalogram (EEG) in 9CD patients under VNS at 10 Hz just before VNS initiation, after 6 weeks and after 12 months of chronic VNS.
Acute VNS induced increased spectral power in delta and theta bands on frontal, temporal and occipital electrodes. The main significant modulation was the 12 months' chronic effect of VNS which consisted mainly in a decreased power in the alpha frequency band which was correlated with the normalization of bowel mucosal inflammation, anxiety state and vagal tone.
In addition to the activation of vagal efferent fibers that regulate the autonomic nervous system, our data suggest that chronic VNS has a regulatory action via afferent vagal fibers on anxio-depressive symptomatology associated to CD, which could be directly highlighted by the modulation of EEG alpha power known to be associated to depressed states.
This is the first report of the central effects of VNS in CD patients.
在首例迷走神经刺激（VNS）治疗克罗恩病（CD）的临床试验中，我们的主要目的是定量评估 VNS 对 CD 患者大脑活动的急性和慢性影响。
我们在 VNS 开始前、6 周后和 12 个月慢性 VNS 后，对 9 名 CD 患者在 10 Hz 下进行了脑电图（EEG）测量。
急性 VNS 在前额、颞叶和枕叶电极引起了 delta 和 theta 频段的频谱功率增加。主要的显著调制是 12 个月的慢性 VNS 效应，主要表现为 alpha 频段的功率降低，与肠黏膜炎症、焦虑状态和迷走神经张力的正常化相关。
除了激活调节自主神经系统的迷走传出纤维外，我们的数据还表明，慢性 VNS 通过与 CD 相关的焦虑-抑郁症状的传入迷走纤维发挥调节作用，这可以通过 EEG alpha 功率的调制直接突出，已知该调制与抑郁状态相关。
这是首次报道 VNS 对 CD 患者的中枢影响。
