Department of Mathematics, University of Sussex, Brighton BN1 9QH, UK.
Department of Mathematics, University of Sussex, Brighton BN1 9QH, UK.
J Theor Biol. 2018 Jun 14;447:98-110. doi: 10.1016/j.jtbi.2018.03.025. Epub 2018 Mar 21.
A new detailed mathematical model for dynamics of immune response to hepatitis B is proposed, which takes into account contributions from innate and adaptive immune responses, as well as cytokines. Stability analysis of different steady states is performed to identify parameter regions where the model exhibits clearance of infection, maintenance of a chronic infection, or periodic oscillations. Effects of nucleoside analogues and interferon treatments are analysed, and the critical drug efficiency is determined.
提出了一个新的详细的乙型肝炎免疫反应动力学数学模型，该模型考虑了先天和适应性免疫反应以及细胞因子的贡献。进行了不同稳定状态的稳定性分析，以确定模型表现出清除感染、维持慢性感染或周期性振荡的参数区域。分析了核苷类似物和干扰素治疗的效果，并确定了临界药物效率。
