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Mathematical Modeling for Hepatitis B Virus: Would Spatial Effects Play a Role and How to Model It?

作者信息

Means Shawn, Ali Md A, Ho Harvey, Heffernan Jane

机构信息

School of Natural and Computational Sciences, Massey University, Auckland, New Zealand.

Department of Mathematics and Statistics, York University, Toronto, ON, Canada.

出版信息

Front Physiol. 2020 Feb 25;11:146. doi: 10.3389/fphys.2020.00146. eCollection 2020.

DOI:10.3389/fphys.2020.00146
PMID:32158403
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7052012/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/899c/7052012/4d784fba821b/fphys-11-00146-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/899c/7052012/4d784fba821b/fphys-11-00146-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/899c/7052012/4d784fba821b/fphys-11-00146-g0001.jpg

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本文引用的文献

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A computational model for hepatotoxicity by coupling drug transport and acetaminophen metabolism equations.耦合药物转运和对乙酰氨基酚代谢方程的肝毒性计算模型。
Int J Numer Method Biomed Eng. 2019 Sep;35(9):e3234. doi: 10.1002/cnm.3234. Epub 2019 Jul 28.
2
Quantitative systems pharmacology of interferon alpha administration: A multi-scale approach.干扰素 α 给药的定量系统药理学：多尺度方法。
PLoS One. 2019 Feb 13;14(2):e0209587. doi: 10.1371/journal.pone.0209587. eCollection 2019.
3
Mathematical model of immune response to hepatitis B.
Sci Rep. 2024 Mar 4;14(1):5328. doi: 10.1038/s41598-024-55111-8.
4
A computational spatial whole-Cell model for hepatitis B viral infection and drug interactions.乙型肝炎病毒感染和药物相互作用的计算空间全细胞模型。
Sci Rep. 2023 Dec 4;13(1):21392. doi: 10.1038/s41598-023-45998-0.
5
Analysis of HBV and COVID-19 Coinfection Model with Intervention Strategies.HBV 和 COVID-19 合并感染模型与干预策略分析。
Comput Math Methods Med. 2023 Sep 29;2023:6908757. doi: 10.1155/2023/6908757. eCollection 2023.
6
Global sensitivity analysis of a single-cell HBV model for viral dynamics in the liver.用于肝脏病毒动力学的单细胞乙肝病毒模型的全局敏感性分析。
Infect Dis Model. 2021 Oct 27;6:1220-1235. doi: 10.1016/j.idm.2021.10.003. eCollection 2021.
7
Efficient Methods for Parameter Estimation of Ordinary and Partial Differential Equation Models of Viral Hepatitis Kinetics.病毒性肝炎动力学常微分方程模型和偏微分方程模型参数估计的有效方法
Mathematics (Basel). 2020 Sep;8(9). doi: 10.3390/math8091483. Epub 2020 Sep 2.
乙型肝炎免疫反应的数学模型。
J Theor Biol. 2018 Jun 14;447:98-110. doi: 10.1016/j.jtbi.2018.03.025. Epub 2018 Mar 21.
4
3D microfluidic liver cultures as a physiological preclinical tool for hepatitis B virus infection.作为乙型肝炎病毒感染生理学前临床工具的3D微流控肝脏培养物
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Antiviral Res. 2015 Oct;122:91-100. doi: 10.1016/j.antiviral.2015.08.005. Epub 2015 Aug 10.
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Lancet. 2015 Oct 17;386(10003):1546-55. doi: 10.1016/S0140-6736(15)61412-X. Epub 2015 Jul 28.
10
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Antiviral Res. 2015 Sep;121:152-9. doi: 10.1016/j.antiviral.2015.07.006. Epub 2015 Jul 20.