Weiser B, Burger H, Steimer K, Lifson J, Engleman E, Grimson R, Robinson W S
J Med Virol. 1987 Jul;22(3):237-44. doi: 10.1002/jmv.1890220307.
To examine the relationship between human immunodeficiency virus (HIV) seropositivity and T lymphocyte subsets in a clinically well population, we assayed HIV antibody and analyzed T lymphocyte subsets in 30 people at increased risk for acquired immunodeficiency syndrome (AIDS) who were clinically well. Seventy-six percent of the HIV-seropositive individuals had abnormally low numbers of T helper lymphocytes, and HIV seropositivity was strongly correlated with an abnormally low number of T helper cells (p less than 0.00002). Among these clinically well subjects at increased risk for AIDS, HIV-sero-positive individuals had a significant decrease in mean T helper lymphocytes and mean T helper:T suppressor ratios as compared to those who were seronegative (483 cells/mm3 vs 915 cells/mm3, p less than 0.002; and 0.80 vs 1.7, p less than 0.002, respectively). Because of the strong correlation of HIV seropositivity and abnormally low numbers of T helper lymphocytes in this asymptomatic population, these findings suggest that asymptomatic seropositive individuals should be followed closely for development of AIDS-related disease and should be considered for future antiviral therapy when it becomes available.
为了研究在临床状况良好的人群中人类免疫缺陷病毒（HIV）血清阳性与T淋巴细胞亚群之间的关系，我们对30名获得性免疫缺陷综合征（AIDS）风险增加但临床状况良好的人进行了HIV抗体检测并分析了T淋巴细胞亚群。76%的HIV血清阳性个体辅助性T淋巴细胞数量异常低，且HIV血清阳性与辅助性T细胞数量异常低密切相关（p<0.00002）。在这些AIDS风险增加但临床状况良好的受试者中，与血清阴性者相比，HIV血清阳性个体的平均辅助性T淋巴细胞和平均辅助性T细胞：抑制性T细胞比值显著降低（分别为483个细胞/mm³对915个细胞/mm³，p<0.002；以及0.80对1.7，p<0.002）。由于在这个无症状人群中HIV血清阳性与辅助性T淋巴细胞数量异常低密切相关，这些发现表明，对于无症状血清阳性个体应密切随访以观察是否发生与AIDS相关的疾病，并且当未来有抗病毒治疗可用时应考虑对其进行治疗。
