Eyster M E, Gail M H, Ballard J O, Al-Mondhiry H, Goedert J J
Ann Intern Med. 1987 Jul;107(1):1-6. doi: 10.7326/0003-4819-107-1-1.
Serial T-cell subsets and platelet counts were determined in a cohort of 84 hemophiliacs in whom time of seroconversion for human immunodeficiency virus (HIV) antibody could be ascertained. An abrupt decrease in the number of T-helper (T4) cells was seen in 9 patients 12 to 24 months before the acquired immunodeficiency syndrome (AIDS) was diagnosed (p = 0.0007 compared with those who did not develop AIDS). Thrombocytopenia also was associated with an increased risk for AIDS (p = 0.02), as was older age at the time of seroconversion (p = 0.03). Ten patients developed AIDS at 24 to 95 months after seroconversion, for a cumulative incidence (+/- SE) of 18.0% +/- 7.1% at 6 years. Hemophiliacs who had T4 cell counts of less than 200 cells/microL had a 50% +/- 16% cumulative incidence of AIDS within 2 years, indicating that decreasing or very low T4 cell counts have predictive value for the development of AIDS. Furthermore, the data suggest that thrombocytopenia and older age may be markers for a cofactor that increases the risk for AIDS in hemophiliacs.
在一组84名血友病患者中测定了系列T细胞亚群和血小板计数，这些患者可确定其人类免疫缺陷病毒（HIV）抗体血清转化时间。在获得性免疫缺陷综合征（AIDS）确诊前12至24个月，9名患者出现T辅助（T4）细胞数量突然减少（与未患AIDS的患者相比，p = 0.0007）。血小板减少症也与患AIDS的风险增加相关（p = 0.02），血清转化时年龄较大也有此关联（p = 0.03）。10名患者在血清转化后24至95个月患AIDS，6年时的累积发病率（±标准误）为18.0%±7.1%。T4细胞计数低于200个/微升的血友病患者在2年内AIDS的累积发病率为50%±16%，这表明T4细胞计数减少或极低对AIDS的发生具有预测价值。此外，数据表明血小板减少症和年龄较大可能是增加血友病患者患AIDS风险的一种辅助因素的标志。
