用羟氯喹治疗斑秃：9例儿科病例的回顾性研究
Alopecia areata treated with hydroxychloroquine: A retrospective study of nine pediatric cases.
作者信息
Yun Duri, Silverberg Nanette B, Stein Sarah L
机构信息
Division of Dermatology, University of Chicago Medicine, Chicago, IL, USA.
Mt Sinai St. Luke's-Roosevelt Hospital Center, Mt Sinai Beth Israel Medical Center, New York, NY, USA.
出版信息
Pediatr Dermatol. 2018 May;35(3):361-365. doi: 10.1111/pde.13451. Epub 2018 Mar 25.
BACKGROUND/OBJECTIVES: Alopecia areata is a common hair loss condition that is often emotionally devastating for patients. There is a paucity of effective treatments available. Hydroxychloroquine has been reported as variably effective in inducing significant hair regrowth in adults with alopecia areata. The objective of this retrospective study was to assess the benefit and tolerability of hydroxychloroquine in pediatric alopecia areata.
METHODS
We conducted a retrospective review of nine children with a history of alopecia areata treated with hydroxychloroquine. Clinical data were obtained from patients treated at two tertiary care centers in the United States between July 1, 2013, and July 1, 2015.
RESULTS
Alopecia scores of five patients improved by 6 months of treatment. Four patients experienced no improvement from baseline evaluation. The most common side effect associated with treatment was gastrointestinal intolerance and headache.
CONCLUSION
This retrospective series suggests that hydroxychloroquine can be considered as a treatment option for alopecia areata in children.
背景/目的：斑秃是一种常见的脱发疾病，往往给患者带来情感上的重创。目前有效的治疗方法匮乏。据报道，羟氯喹在诱导成年斑秃患者显著毛发再生方面效果不一。这项回顾性研究的目的是评估羟氯喹治疗儿童斑秃的疗效和耐受性。
方法
我们对9例有斑秃病史且接受羟氯喹治疗的儿童进行了回顾性分析。临床数据来自2013年7月1日至2015年7月1日在美国两个三级医疗中心接受治疗的患者。
结果
5例患者经6个月治疗后脱发评分有所改善。4例患者与基线评估相比无改善。与治疗相关的最常见副作用是胃肠道不耐受和头痛。
结论
这个回顾性系列研究表明，羟氯喹可被视为儿童斑秃的一种治疗选择。
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