School of Chemical Engineering and Technology, Key Laboratory of Systems Bioengineering (Ministry of Education), Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Tianjin University, Tianjin, 300072, P. R. China.
Small. 2018 Apr;14(16):e1800185. doi: 10.1002/smll.201800185. Epub 2018 Mar 25.
Metal nanoclusters (NCs) possess unique optical properties, and exhibit a wide variety of potential applications. DNA with robust molecular programmability is demonstrated as an ideal scaffold to regulate the formation of NCs, offering a rational approach to precisely tune the spatial structures of NCs. Herein, the first use of branched DNA as scaffold to regulate the formation of silver nanoclusters (super-AgNC) is reported, in which the spatial structures are precisely designed and constructed. Super-AgNC with tunable shapes and arm-lengths including Y-, X-, and (Y-X)- shaped super-AgNC is achieved. The molecular structures and optical properties of super-AgNCs are systemically studied. As a proof of application, remarkably, super-AgNCs exhibit superior antibacterial performance. In addition, super-AgNCs show excellent biocompatibility with three types of tissue cells including 293T (human embryonic kidney cells), SMCs (vascular smooth muscle cells), and GLC-82 (lung adenocarcinoma cells). These performances enable the super-AgNCs adaptable in a variety of applications such as biosensing, bioimaging, and antibacterial agents.
金属纳米团簇 (NCs) 具有独特的光学性质，并表现出广泛的潜在应用。具有强大分子可编程性的 DNA 被证明是调控 NCs 形成的理想支架，为精确调整 NCs 的空间结构提供了一种合理的方法。在此，首次报道了使用分支 DNA 作为支架来调控银纳米团簇 (超 AgNC) 的形成，其中空间结构被精确设计和构建。实现了具有可调形状和臂长的超 AgNC，包括 Y-、X-和 (Y-X)-形超 AgNC。系统研究了超 AgNC 的分子结构和光学性质。作为应用的证明，值得注意的是，超 AgNC 表现出优异的抗菌性能。此外，超 AgNC 与三种组织细胞（293T（人胚肾细胞）、SMC（血管平滑肌细胞）和 GLC-82（肺腺癌细胞））具有良好的生物相容性。这些性能使超 AgNC 能够适应各种应用，如生物传感、生物成像和抗菌剂。
