Kim Ki-Beom, Kim Sang-Ho, Yoo Seung-Min
School of Integrative Engineering, Chung-Ang University, Seoul 06974, Republic of Korea.
Biosensors (Basel). 2024 Dec 18;14(12):625. doi: 10.3390/bios14120625.
Metal nanoclusters (NCs) are promising alternatives to organic dyes and quantum dots. These NCs exhibit unique physical and chemical properties, such as fluorescence, chirality, magnetism and catalysis, which contribute to significant advancements in biosensing, biomedical diagnostics and therapy. Through adjustments in composition, size, chemical environments and surface ligands, it is possible to create NCs with tunable optoelectronic and catalytic activity. This review focuses on the integration of aptamers with metal NCs, detailing molecular detection strategies that utilise the effect of aptamers on optical signal emission of metal NC-based biosensing systems. This review also highlights recent advancements in biosensing and biomedical applications, as well as illustrative case studies. To conclude, the strengths, limitations, current challenges and prospects for metal NC-based systems were examined.
金属纳米团簇（NCs）是有机染料和量子点很有前景的替代物。这些纳米团簇具有独特的物理和化学性质，如荧光、手性、磁性和催化性，这有助于生物传感、生物医学诊断和治疗取得重大进展。通过调整组成、尺寸、化学环境和表面配体，可以制造出具有可调谐光电和催化活性的纳米团簇。本综述重点关注适体与金属纳米团簇的整合，详细介绍利用适体对基于金属纳米团簇的生物传感系统光信号发射的影响的分子检测策略。本综述还强调了生物传感和生物医学应用的最新进展以及说明性案例研究。最后，研究了基于金属纳米团簇的系统的优势、局限性、当前挑战和前景。
