Eye Hospital of China Academy of Chinese Medical Sciences, Beijing, China.
Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
Acta Ophthalmol. 2018 Aug;96(5):e570-e576. doi: 10.1111/aos.13724. Epub 2018 Mar 24.
To compare the orbital cerebral spinal fluid pressure (CSFP) and trans-lamina cribrosa pressure difference (TLCPD) determined noninvasively in ocular hypertensive (OH) subjects and controls.
Cross-sectional observational study. Magnetic resonance imaging was used to measure orbital subarachnoid space width (OSASW). The CSFP (mm Hg) was estimated from a published formula as 17.54 × MRI derived OSASW at 15 mm behind the globe + 0.47 × body mass index + 0.13 × mean arterial blood pressure -21.52. Estimated TLCPD was calculated as IOP- CSFP.
The orbital subarachnoid space width was significantly wider (p = 0.01) in the OH group than in the control group at all three measurement locations. The MRI derived CSFP value in OH (14.9 ± 2.9 mm Hg) was significantly higher than in the normal group (12.0 ± 2.8 mm Hg; p < 0.01). The estimated TLCPD value in OH (9.0 ± 4.2 mm Hg) was significantly higher than in controls (3.6 ± 3.0 mm Hg; p < 0.01).
The wider OSASW and higher estimated CSFP in OH subjects suggest a higher orbital CSFP. Despite a higher orbital CSFP that could be protective, the higher TLCPD in OH may play a significant role in the risk of developing glaucoma.
比较非侵入性测量的高眼压（OH）患者和对照组眶内脑脊髓液压力（CSFP）和经筛板压力差（TLCPD）。
横断面观察性研究。磁共振成像（MRI）用于测量眶蛛网膜下腔宽度（OSASW）。CSFP（mmHg）由已发表的公式估算得出：17.54×MRI 得出的眼球后 15mm 处 OSASW+0.47×体重指数+0.13×平均动脉血压-21.52。估计的 TLCPD 计算为 IOP-CSF。
OH 组在所有三个测量位置的眶蛛网膜下腔宽度均明显较宽（p=0.01）。OH 组的 MRI 得出的 CSFP 值（14.9±2.9mmHg）明显高于正常组（12.0±2.8mmHg；p<0.01）。OH 组的估计 TLCPD 值（9.0±4.2mmHg）明显高于对照组（3.6±3.0mmHg；p<0.01）。
OH 患者 OSASW 更宽和 CSFP 值更高提示眶内 CSFP 更高。尽管较高的眶内 CSFP 可能具有保护作用，但 OH 中较高的 TLCPD 可能在青光眼发病风险中发挥重要作用。
