正视眼和近视眼眼球后段视神经、蛛网膜下腔和视神经鞘的超高磁场磁共振成像。

Ultra-High Field Magnetic Resonance Imaging of the Retrobulbar Optic Nerve, Subarachnoid Space, and Optic Nerve Sheath in Emmetropic and Myopic Eyes.

机构信息

Department of Optometry and Vision Sciences, The University of Melbourne, Parkville, Victoria, Australia.

Melbourne Brain Centre Imaging Unit, Department of Medicine and Radiology, The University of Melbourne, Parkville, Victoria, Australia.

出版信息

Transl Vis Sci Technol. 2021 Feb 5;10(2):8. doi: 10.1167/tvst.10.2.8.

PURPOSE

We aimed to image the optic nerve, subarachnoid space and optic nerve sheath in emmetropes and myopes ultra-high field (7-Tesla) magnetic resonance imaging (MRI). We targeted the retrobulbar distance of approximately 3 mm behind the eyeball, an area of clinical interest because of optic nerve sheath distensibility and pressure-related enlargement.

METHODS

Eleven emmetropes (+0.75 to -0.50D, aged 20-41 years) and 10 myopes (-4.5 to -12D, aged 21-37 years) participated. Cross-sectional area of the optic nerve, subarachnoid space and optic nerve sheath at approximately 3 mm behind the eye were measured from two-dimensional T2-weighted coronal oblique MRI images obtained through the left optic nerve. Axial length of the left eye was measured from T2-weighted axial MRI images. In nine emmetropes and seven myopes, the optic nerve head was imaged with optical coherence tomography to compare retrobulbar and intraocular measures.

RESULTS

Retrobulbar optic nerve, subarachnoid space and optic nerve sheath dimensions differed between myopes and emmetropes. Myopes tended to have smaller optic nerve and subarachnoid space. Longer MRI-derived axial length was associated with smaller optic nerve area (P = 0.03). Bruch's membrane opening area did not predict retrobulbar optic nerve area (P = 0.48).

CONCLUSIONS

This study demonstrates the feasibility of using 7-Tesla MRI to measure optic nerve, subarachnoid space, and optic nerve sheath dimensions behind the eye. In healthy adults, the retrobulbar optic nerve and subarachnoid space size are influenced by the degree of myopia.

TRANSLATIONAL RELEVANCE

ultra-high field MRI is a practical tool for assessing the morphometry of the optic nerve and surrounding anatomy behind the eye.

目的

我们旨在对正视眼和近视患者的视神经、蛛网膜下腔和视神经鞘进行超高场（7 特斯拉）磁共振成像（MRI）成像。我们的目标是眼球后约 3 毫米的眶后距离，该区域是临床关注的焦点，因为视神经鞘具有可扩张性和与压力相关的扩大。

方法

11 名正视眼（+0.75 至-0.50D，年龄 20-41 岁）和 10 名近视患者（-4.5 至-12D，年龄 21-37 岁）参与了研究。通过从左侧视神经获得的二维 T2 加权冠状斜位 MRI 图像测量眼球后约 3 毫米处视神经、蛛网膜下腔和视神经鞘的横截面积。左眼眼轴长度从 T2 加权轴向 MRI 图像中测量。在 9 名正视眼和 7 名近视患者中，使用光学相干断层扫描对视神经头进行成像，以比较眶内和眼内测量值。

结果

近视患者和正视眼患者的眶内视神经、蛛网膜下腔和视神经鞘尺寸不同。近视患者的视神经和蛛网膜下腔较小。较长的 MRI 衍生轴长与较小的视神经面积相关（P=0.03）。Bruch 膜开口面积与眶内视神经面积无相关性（P=0.48）。

结论

本研究证明了使用 7 特斯拉 MRI 测量眼球后视神经、蛛网膜下腔和视神经鞘尺寸的可行性。在健康成年人中，眶内视神经和蛛网膜下腔的大小受近视程度的影响。

翻译说明

为了更好地传达原文的意思，保留了英文中的一些医学术语，如“optic nerve”（视神经）、“subarachnoid space”（蛛网膜下腔）和“optic nerve sheath”（视神经鞘）。
对原文中的一些缩写进行了扩展，如“MRI”（Magnetic Resonance Imaging，磁共振成像）。
对于一些比较难理解的句子，如“the retrobulbar optic nerve and subarachnoid space size are influenced by the degree of myopia”，进行了拆分翻译，使其更符合中文的表达习惯。