a Department of Medical and Surgical Sciences and Advanced Technologies "G.F. Ingrassia" , University of Catania , Catania , Italy.
b Human Nutrition Research Unit , Medical Research Council (MRC) , Cambridge , UK.
Int J Food Sci Nutr. 2018 Dec;69(8):1020-1029. doi: 10.1080/09637486.2018.1452900. Epub 2018 Mar 26.
Dietary polyphenols, including flavonoids, are abundantly present in a healthy and balanced diet. Evidence for their role in preventing non-communicable diseases is emerging. We examined the association between estimated habitual intake of dietary flavonoid and obesity in a cohort study. After adjusting for potential confounding factors, inverse association between total flavonoid intake and excess weight (BMI ≥25) was found (OR = 0.66, 95% CI: 0.45, 0.99); among individual classes of flavonoids, only flavanones were inversely associated with excess body weight (OR = 0.68, 95% CI: 0.48, 0.97). However, when considering adjustment for dietary factors (adherence to the Mediterranean diet), the associations were no more significant. When considering obesity as the outcome (BMI ≥30), individuals with high intake of total flavonoids and flavonols resulted less likely to be obese (OR = 0.38, 95% CI: 0.21, 0.66 and OR = 0.63, 95% CI: 0.39, 0.99, respectively), even after adjustment for confounding factors. The results of the present study add to the current literature further evidence of the association between higher flavonoid intake and decreased body weight. Further studies are needed to confirm retrieved association.
饮食中的多酚类化合物，包括类黄酮，在健康均衡的饮食中含量丰富。有证据表明它们在预防非传染性疾病方面发挥作用。我们在一项队列研究中检查了习惯性饮食类黄酮摄入量与肥胖之间的关系。在调整了潜在的混杂因素后，发现总类黄酮摄入量与超重（BMI≥25）之间呈负相关（OR=0.66，95%CI：0.45，0.99）；在类黄酮的各个类别中，只有黄烷酮与超重呈负相关（OR=0.68，95%CI：0.48，0.97）。然而，当考虑到饮食因素（遵循地中海饮食）的调整时，这些关联就不再显著了。当将肥胖作为结果（BMI≥30）时，高总类黄酮和类黄酮醇摄入量的个体不太可能肥胖（OR=0.38，95%CI：0.21，0.66 和 OR=0.63，95%CI：0.39，0.99，分别），即使在调整了混杂因素后也是如此。本研究的结果进一步证明了较高的类黄酮摄入量与较低的体重之间的关联，为当前的文献增添了证据。需要进一步的研究来证实所发现的关联。
