Gil-Lespinard Mercedes, Castañeda Jazmín, Almanza-Aguilera Enrique, Gómez Jesús Humberto, Tjønneland Anne, Kyrø Cecilie, Overvad Kim, Katzke Verena, Schulze Matthias B, Masala Giovanna, Agnoli Claudia, Santucci de Magistris Maria, Tumino Rosario, Sacerdote Carlotta, Skeie Guri, Lasheras Cristina, Molina-Montes Esther, Huerta José María, Barricarte Aurelio, Amiano Pilar, Sonestedt Emily, da Silva Marisa, Johansson Ingegerd, Hultdin Johan, May Anne M, Forouhi Nita G, Heath Alicia K, Freisling Heinz, Weiderpass Elisabete, Scalbert Augustin, Zamora-Ros Raul
Unit of Nutrition and Cancer, Cancer Epidemiology Research Programme, Catalan Institute of Oncology (ICO), Bellvitge Biomedical Research Institute (IDIBELL), 08908 Barcelona, Spain.
Department of Epidemiology, Regional Health Council, IMIB-Arrixaca, 30008 Murcia, Spain.
Antioxidants (Basel). 2022 Dec 8;11(12):2425. doi: 10.3390/antiox11122425.
Polyphenols are bioactive compounds from plants with antioxidant properties that may have a protective role against body weight gain, with adipose tissue and systemic oxidative stress as potential targets. We aimed to investigate the dietary intake of individual polyphenols and their association with 5-year body weight change in a sub-cohort of the European Prospective Investigation into Cancer and Nutrition (EPIC). This study included 349,165 adult participants from nine European countries. Polyphenol intake was estimated through country-specific validated dietary questionnaires and the Phenol-Explorer database. Body weight was obtained at recruitment and after a mean follow-up time of 5 years. Associations were estimated using multilevel mixed linear regression models. From 91 polyphenols included, the majority (n = 67) were inversely associated with 5-year body weight change after FDR-correction (q < 0.05). The greatest inverse associations were observed for quercetin 3-O-rhamnoside (change in weight for doubling in intake: −0.071 (95% CI: −0.085; −0.056) kg/5 years). Only 13 polyphenols showed positive associations with body weight gain, mainly from the subclass hydroxycinnamic acids (HCAs) with coffee as the main dietary source, such as 4-caffeoylquinic acid (0.029 (95% CI: 0.021; 0.038) kg/5 years). Individual polyphenols with fruit, tea, cocoa and whole grain cereals as the main dietary sources may contribute to body weight maintenance in adults. Individual HCAs may have different roles in body weight change depending on their dietary source.
多酚是植物中的生物活性化合物，具有抗氧化特性，可能对体重增加起到保护作用，其潜在靶点为脂肪组织和全身氧化应激。我们旨在调查欧洲癌症与营养前瞻性调查（EPIC）子队列中个体多酚的饮食摄入量及其与5年体重变化的关联。本研究纳入了来自9个欧洲国家的349,165名成年参与者。通过特定国家验证的饮食问卷和酚类物质探索者数据库估算多酚摄入量。在招募时和平均5年的随访期后获取体重。使用多级混合线性回归模型估算关联。在纳入的91种多酚中，大多数（n = 67）在经FDR校正后（q < 0.05）与5年体重变化呈负相关。槲皮素3 - O - 鼠李糖苷的负相关最为显著（摄入量翻倍时体重变化：−0.071（95% CI：−0.085；−0.056）kg/5年）。只有13种多酚与体重增加呈正相关，主要来自以咖啡为主要饮食来源的羟基肉桂酸（HCAs）亚类，如4 - 咖啡酰奎尼酸（0.029（95% CI：0.021；0.038）kg/5年）。以水果、茶、可可和全谷物为主要饮食来源的个体多酚可能有助于成年人维持体重。根据其饮食来源，个体HCAs在体重变化中可能具有不同作用。
