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胰岛素样生长因子II受体作为一种多功能结合蛋白。

Insulin-like growth factor II receptor as a multifunctional binding protein.

作者信息

Morgan D O, Edman J C, Standring D N, Fried V A, Smith M C, Roth R A, Rutter W J

出版信息

Nature. 1987;329(6137):301-7. doi: 10.1038/329301a0.

DOI:10.1038/329301a0
PMID:2957598
Abstract

The primary structure of human insulin-like growth factor II receptor, predicted from the complementary DNA sequence, reveals a transmembrane receptor molecule with a large extracellular domain made up of fifteen repeat sequences and a small region homologous to the collagen-binding domain of fibronectin. The structural and biochemical features of the IGF-II receptor appear identical to those of the cation-independent mannose-6-phosphate receptor.

摘要

从互补DNA序列预测的人胰岛素样生长因子II受体的一级结构，揭示了一种跨膜受体分子，其具有由15个重复序列组成的大的细胞外结构域和与纤连蛋白的胶原结合结构域同源的小区域。IGF-II受体的结构和生化特征似乎与不依赖阳离子的甘露糖-6-磷酸受体的结构和生化特征相同。

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Insulin-like growth factor II receptor as a multifunctional binding protein.胰岛素样生长因子II受体作为一种多功能结合蛋白。
Nature. 1987;329(6137):301-7. doi: 10.1038/329301a0.
2
A single receptor binds both insulin-like growth factor II and mannose-6-phosphate.单一受体可同时结合胰岛素样生长因子II和甘露糖-6-磷酸。
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The human cation-independent mannose 6-phosphate receptor. Cloning and sequence of the full-length cDNA and expression of functional receptor in COS cells.人阳离子非依赖性甘露糖6-磷酸受体。全长cDNA的克隆与序列分析以及功能性受体在COS细胞中的表达。
J Biol Chem. 1988 Feb 15;263(5):2553-62.
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Genomics. 1994 Jan 1;19(1):120-9. doi: 10.1006/geno.1994.1021.
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Genes encoding receptors for insulin and insulin-like growth factor I are expressed in Xenopus oocytes and embryos.编码胰岛素和胰岛素样生长因子I受体的基因在非洲爪蟾卵母细胞和胚胎中表达。
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Insulin-like growth factor-related genes, receptors, and binding proteins in cultured human retinal pigment epithelial cells.培养的人视网膜色素上皮细胞中的胰岛素样生长因子相关基因、受体及结合蛋白
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Insulin-like growth factor (IGF) binding protein complementary deoxyribonucleic acid from human HEP G2 hepatoma cells: predicted protein sequence suggests an IGF binding domain different from those of the IGF-I and IGF-II receptors.来自人肝癌细胞系HEP G2的胰岛素样生长因子（IGF）结合蛋白互补脱氧核糖核酸：预测的蛋白质序列表明存在一个与IGF-I和IGF-II受体不同的IGF结合结构域。
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46 kd mannose 6-phosphate receptor: cloning, expression, and homology to the 215 kd mannose 6-phosphate receptor.46千道尔顿甘露糖6-磷酸受体：克隆、表达及其与215千道尔顿甘露糖6-磷酸受体的同源性
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Insulin-like growth factor I receptor primary structure: comparison with insulin receptor suggests structural determinants that define functional specificity.胰岛素样生长因子I受体一级结构：与胰岛素受体的比较揭示了决定功能特异性的结构决定因素。
EMBO J. 1986 Oct;5(10):2503-12. doi: 10.1002/j.1460-2075.1986.tb04528.x.
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Primary structure of a putative receptor for a ligand of the insulin family.胰岛素家族一种配体的假定受体的一级结构。
J Biol Chem. 1989 Sep 5;264(25):14605-8.

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