Australian Research Council (ARC) Centre of Excellence in Plant Energy Biology, University of Western Australia, Crawley, Western Australia, Australia.
Department of Biology, Lund University, Sölvegatan 35, 223 62 Lund, Sweden.
Trends Plant Sci. 2018 May;23(5):434-450. doi: 10.1016/j.tplants.2018.02.010. Epub 2018 Mar 22.
Mitophagy is a conserved cellular process that is important for autophagic removal of damaged mitochondria to maintain a healthy mitochondrial population. Mitophagy also appears to occur in plants and has roles in development, stress response, senescence, and programmed cell death. However, many of the genes that control mitophagy in yeast and animal cells are absent from plants, and no plant proteins marking defunct mitochondria for autophagic degradation are yet known. New insights implicate general autophagy-related proteins in mitophagy, affecting the senescence of plant tissues. Mitophagy control and its importance for energy metabolism, survival, signaling, and cell death in plants are discussed. Furthermore, we suggest mitochondrial membrane proteins containing ATG8-interacting motifs, which might serve as mitophagy receptor proteins in plant mitochondria.
线粒体自噬是一种保守的细胞过程，对于通过自噬去除受损的线粒体以维持健康的线粒体群很重要。线粒体自噬似乎也存在于植物中，并在发育、应激反应、衰老和程序性细胞死亡中发挥作用。然而，控制酵母和动物细胞中线粒体自噬的许多基因在植物中缺失，而且目前还不知道有植物蛋白可以标记失效的线粒体进行自噬降解。新的研究结果表明，一般的与自噬相关的蛋白质参与了线粒体自噬，影响了植物组织的衰老。讨论了线粒体自噬的控制及其对植物中能量代谢、生存、信号转导和细胞死亡的重要性。此外，我们还提出了含有 ATG8 相互作用基序的线粒体膜蛋白，它们可能作为植物线粒体中的线粒体自噬受体蛋白。
