钙离子在 Aβ 介导的膜损伤中的主动作用。
The active role of Ca ions in Aβ-mediated membrane damage.
机构信息
Istituto di Biostrutture e Bioimmagini, Consiglio Nazionale delle Ricerche, Sede Secondaria di Catania, Via Paolo Gaifami 18, 95126, Catania, Italy.
出版信息
Chem Commun (Camb). 2018 Apr 5;54(29):3629-3631. doi: 10.1039/c8cc01132j.
PMID:29577161
Abstract
Calcium dysregulation, membrane leakage and Aβ amyloid growth are hallmarks of Alzheimer's disease. Here we show that Ca2+ ions inhibit membrane damage due to amyloid channels but enhance membrane disruption associated with fibers growing on the lipid surface. The similarities with IAPP suggest that this may represent a mechanism common to all proteinopathies.
摘要
钙失调、膜渗漏和 Aβ 淀粉样蛋白生长是阿尔茨海默病的标志。在这里，我们表明 Ca2+ 离子抑制由于淀粉样通道导致的膜损伤，但增强与在脂质表面上生长的纤维相关的膜破坏。与 IAPP 的相似性表明，这可能代表所有蛋白质病的共同机制。
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