Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne & Melbourne Health, Carlton South, VIC, Australia.
Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne & Melbourne Health, Carlton South, VIC, Australia; The Cooperative Research Centre (CRC) for Mental Health, Victoria, Australia.
Prog Neuropsychopharmacol Biol Psychiatry. 2018 Jul 13;85:1-6. doi: 10.1016/j.pnpbp.2018.03.010. Epub 2018 Mar 22.
Upregulation of selenium binding protein 1 (SELENBP1) mRNA expression has been reported in schizophrenia, primarily in the dorsolateral prefrontal cortex. However, peripheral blood studies are limited and results are inconsistent. In this study, we examined SELENBP1 mRNA expression in whole blood and protein expression in plasma from patients with recent-onset schizophrenia (n = 30), treatment-resistant schizophrenia (n = 71) and healthy controls (n = 57). We also examined the effects of SELENBP1 genetic variation on gene and protein expression. We found lower SELENBP1 plasma protein levels in patients with recent-onset schizophrenia (p = 0.042) but not in treatment-resistant schizophrenia (p = 0.81). Measurement of peripheral mRNA levels showed no difference between treatment-resistant schizophrenia and healthy controls (p = 0.234) but clozapine plasma levels (p = 0.036) and duration of illness (p = 0.028) were positively correlated with mRNA levels. Genetic variation was not associated with mRNA or protein expression. Our data represent the first peripheral proteomic study of SELENBP1 in schizophrenia and suggest that plasma SELENBP1 protein is downregulated in patients with recent-onset schizophrenia.
硒结合蛋白 1（SELENBP1）mRNA 表达上调已在精神分裂症中报道，主要在背外侧前额叶皮层。然而，外周血研究有限，结果不一致。在这项研究中，我们检查了初发精神分裂症患者（n=30）、抗治疗精神分裂症患者（n=71）和健康对照组（n=57）的全血 SELENBP1 mRNA 表达和血浆蛋白表达。我们还检查了 SELENBP1 遗传变异对基因和蛋白表达的影响。我们发现初发精神分裂症患者的 SELENBP1 血浆蛋白水平较低（p=0.042），但在抗治疗精神分裂症患者中没有（p=0.81）。抗治疗精神分裂症患者和健康对照组之间外周 mRNA 水平的测量没有差异（p=0.234），但氯氮平血浆水平（p=0.036）和病程（p=0.028）与 mRNA 水平呈正相关。遗传变异与 mRNA 或蛋白表达无关。我们的数据代表了精神分裂症中 SELENBP1 的首个外周蛋白质组学研究，表明初发精神分裂症患者的血浆 SELENBP1 蛋白下调。
