Aoki I, Ishii N, Minami M, Nagashima Y, Misugi K, Okuda K
Transplantation. 1987 Sep;44(3):421-5. doi: 10.1097/00007890-198709000-00019.
Intravenously administered monoclonal anti-I-A antibodies successfully induced suppressor T (Ts) cells specific for alloantigen-specific delayed-type hypersensitivity (DTH) responses in mice. These Ts cells exerted their effects in the effector phase and had no H-2 restrictions. Phenotypic analysis revealed L3T4 antigens on their cell surface but failed to reveal Lyt-2 antigen. Ts cell activity was abrogated by a 30-min incubation with the anti-I-A antibodies used for Ts cell induction. Incubation in the anti-I-A-antibody-coated plate also abrogated the Ts cell activity. Since anti-I-A antibody is idiotypic for the I-A antigen, it is suggested that these Ts cells might express antiidiotypic receptors for I-A antigens. These findings are considered to be consistent with previous observations of hapten-specific systems, in which antiidiotypic Ts cells are inducible by idiotypic antibodies.
静脉注射单克隆抗I-A抗体成功诱导出了对同种异体抗原特异性迟发型超敏反应（DTH）具有特异性的抑制性T（Ts）细胞。这些Ts细胞在效应阶段发挥作用，且没有H-2限制。表型分析显示其细胞表面有L3T4抗原，但未显示Lyt-2抗原。用用于诱导Ts细胞的抗I-A抗体孵育30分钟可消除Ts细胞活性。在抗I-A抗体包被的平板中孵育也可消除Ts细胞活性。由于抗I-A抗体是I-A抗原的独特型，因此提示这些Ts细胞可能表达I-A抗原的抗独特型受体。这些发现被认为与先前对半抗原特异性系统的观察结果一致，在该系统中，独特型抗体可诱导抗独特型Ts细胞。
