Finci L, Meier B, De Bruyne B, Steffenino G, Divernois J, Rutishauser W
Am J Cardiol. 1987 Sep 1;60(7):467-70. doi: 10.1016/0002-9149(87)90287-6.
In 100 consecutive patients undergoing multivessel percutaneous transluminal coronary angioplasty (PTCA), dilation was attempted in 207 arteries. Primary success was achieved in 85 patients. Complications occurred in 8 patients: acute myocardial infarction in 5 and need for emergency coronary artery bypass surgery in 5. Control angiography was done in 77 of 85 patients (91%) with primary success at a mean of 12 +/- 6 months. Complete revascularization had been achieved in 59 patients and incomplete revascularization in 18. Angiographic restenosis was found in 39 of 77 patients (51%) and in 47 of 143 arteries (33%) at 9 +/- 7 months. The restenosis rate was 57% for chronic total occlusions (8 of 14) and 30% for stenoses (39 of 129). The restenosis rate was significantly higher for the left anterior descending coronary artery (40%) than for the left circumflex coronary artery (21%). However, the significance was lost after exclusion of chronic total occlusions. A higher residual stenosis and a high coronary wedge pressure were predictors for restenosis. Restenosis was clinically silent in 14 patients (18%). Repeat PTCA was done in 19 patients with recurrence and elective surgery in 8. Clinical follow-up was available in all patients at 24 +/- 12 months. Patients with incomplete revascularization had less favorable clinical follow-up results than patients with complete revascularization: 44% (8 of 18) vs 81% (48 of 59) were asymptomatic (p less than 0.005), and 28% (5 of 18) vs 5% (3 of 59) had undergone elective bypass surgery during follow-up (p less than 0.005). Most patients with restenosis after multivessel PTCA had only 1-vessel restenosis and only 7% had restenosis of all lesions.
在100例连续接受多支血管经皮腔内冠状动脉成形术(PTCA)的患者中,共对207条动脉进行了扩张尝试。85例患者取得了初步成功。8例患者出现并发症:5例发生急性心肌梗死,5例需要进行急诊冠状动脉搭桥手术。85例初步成功的患者中有77例(91%)在平均12±6个月时进行了对照血管造影。59例患者实现了完全血运重建,18例为不完全血运重建。77例患者中有39例(51%)在9±7个月时出现血管造影再狭窄,143条动脉中有47条(33%)出现再狭窄。慢性完全闭塞病变的再狭窄率为57%(14例中的8例),狭窄病变的再狭窄率为30%(129例中的39例)。左前降支冠状动脉的再狭窄率(40%)显著高于左旋支冠状动脉(21%)。然而,排除慢性完全闭塞病变后,这种差异不再显著。较高的残余狭窄和较高的冠状动脉楔压是再狭窄的预测因素。14例患者(18%)的再狭窄在临床上无明显症状。19例复发患者接受了再次PTCA,8例接受了择期手术。所有患者均在24±12个月时进行了临床随访。不完全血运重建的患者临床随访结果不如完全血运重建的患者:无症状患者比例分别为44%(18例中的8例)和81%(59例中的48例)(p<0.005),随访期间接受择期搭桥手术的患者比例分别为28%(18例中的5例)和5%(59例中的3例)(p<0.005)。多支血管PTCA术后发生再狭窄的大多数患者仅为单支血管再狭窄,只有7%的患者所有病变均出现再狭窄。