Guiedem Elise, Ikomey George Mondinde, Nkenfou Céline, Walter Pefura-Yone Eric, Mesembe Martha, Chegou Novel Njweipi, Jacobs Graeme Brendon, Okomo Assoumou Marie Claire
Center for the Study and Control of Communicable Diseases (CSCCD), Faculty of Medicine and Biomedical Sciences, University of Yaounde 1, Yaoundé, Cameroon.
Chantal BIYA International Reference Centre for Research on HIV/AIDS Prevention and Management (CBIRC), Yaoundé, Cameroon.
BMC Res Notes. 2018 Mar 27;11(1):192. doi: 10.1186/s13104-018-3309-6.
The inflammatory profile of chronic obstructive pulmonary disease (COPD) related to tobacco is known in certain studies while that of the post tuberculosis form is not yet known. This study aimed to evaluate the levels of neutrophils, macrophages and lymphocytes cells in sputum of COPD patients with history of smoking or anterior tuberculosis. Enumeration of cells in samples was analyzed using standard microscopy.
We enrolled 92 participants, 46 (50%) were COPD subjects comprising 22 (47.83%) smokers and 24 (52.17%) with anterior tuberculosis while 46 (50%) healthy persons constituted the control group. The levels of neutrophils, lymphocytes and monocytes were statistically higher in COPD patients compared to the control group with p-values of 0.0001 respectively. Neutrophils levels were higher in COPD patients with history of tobacco than in COPD patients with anterior tuberculosis with a mean rate of 4.72 × 10/ml and 2.48 × 10/ml respectively (p = 0.04). The monocytes and lymphocytes levels were not statistically different between the two sub-groups of COPD patients with p-value of 0.052 and 0.91 respectively. Neutrophils are the only inflammatory cells that were significantly higher in COPD patients with history of smoking as compared to COPD patients with anterior tuberculosis.
在某些研究中已了解与烟草相关的慢性阻塞性肺疾病（COPD）的炎症特征，而肺结核后形式的炎症特征尚不清楚。本研究旨在评估有吸烟史或既往肺结核病史的COPD患者痰液中中性粒细胞、巨噬细胞和淋巴细胞的水平。使用标准显微镜分析样本中的细胞计数。
我们招募了92名参与者，46名（50%）为COPD受试者，其中22名（47.83%）为吸烟者，24名（52.17%）有既往肺结核病史，而46名（50%）健康人构成对照组。与对照组相比，COPD患者的中性粒细胞、淋巴细胞和单核细胞水平在统计学上更高，p值分别为0.0001。有吸烟史的COPD患者的中性粒细胞水平高于有既往肺结核病史的COPD患者，平均比率分别为4.72×10/ml和2.48×10/ml（p = 0.04）。COPD患者的两个亚组之间的单核细胞和淋巴细胞水平在统计学上没有差异，p值分别为0.052和0.91。与有既往肺结核病史的COPD患者相比，有吸烟史的COPD患者中唯一显著更高的炎症细胞是中性粒细胞。
