自噬在细胞内白细胞介素-1β（IL-1β）的输出和释放中的作用。
Role of autophagy in IL-1β export and release from cells.
机构信息
Autophagy Inflammation and Metabolism Center of Biomedical Research Excellence, University of New Mexico Health Sciences Center, 915 Camino de Salud, NE, Albuquerque, NM 87131 USA; Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, 915 Camino de Salud, NE, Albuquerque, NM 87131 USA.
Autophagy Inflammation and Metabolism Center of Biomedical Research Excellence, University of New Mexico Health Sciences Center, 915 Camino de Salud, NE, Albuquerque, NM 87131 USA; Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, 915 Camino de Salud, NE, Albuquerque, NM 87131 USA.
出版信息
Semin Cell Dev Biol. 2018 Nov;83:36-41. doi: 10.1016/j.semcdb.2018.03.012. Epub 2018 Apr 5.
The autophagy pathway known also as macroautophagy (herein referred to as autophagy) is characterized by the formation of double-membrane organelles that capture cytosolic material. Based on pathway termination alternatives, autophagy has been divided into degradative and secretory. During degradative autophagy, autophagosomes typically fuse with lysosomes upon which the sequestered material is degraded. During secretory autophagy, instead of degradation the sequestered cargo is subjected to active secretion or passive release. In this review, we focus on the mechanisms of secretion/passive release of the potent pro-inflammatory cytokine IL-1β, as a prototypical leaderless cytosolic protein cargo studied in the context of secretory autophagy.
自噬途径又称为巨自噬（下文简称为自噬），其特征是形成捕获胞质物质的双层膜细胞器。根据途径终止的选择，自噬可分为降解性自噬和分泌性自噬。在降解性自噬中，自噬体通常与溶酶体融合，然后被隔离的物质被降解。在分泌性自噬中，被隔离的货物被主动分泌或被动释放，而不是降解。在这篇综述中，我们重点关注强效促炎细胞因子 IL-1β的分泌/被动释放机制，IL-1β是研究分泌性自噬中无信号肽的胞质蛋白货物的典型代表。
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