Gore Mitchell R
Syracuse, USA.
BMC Ear Nose Throat Disord. 2018 Mar 21;18:4. doi: 10.1186/s12901-018-0052-5. eCollection 2018.
Sarcomas comprise a diverse group of soft tissue mesenchymal malignancies. The sinuses and nasal region are a relatively rare site of sarcomas.
Retrospective review of the literature on sinonasal sarcomas from 1987-2017. Data were analyzed for demographics, treatment type, stage, and histopathologic type. Kaplan-Meier analysis was used to assess and compare survival.
A total of 198 cases of sinonasal sarcoma were identified and analyzed. The median age at diagnosis was 39 years. Overall 5-, 10-, and 20-year survival was 61.3%, 58.9%, and 49.1%, respectively, and disease-free 5-, 10-, and 20-year survival was 53.2%, 49.1%, and 38.3%, respectively. Lymph node metastasis was present at diagnosis in 3.0% of cases, and distant metastasis was present in 3.5% of cases. On univariate analysis T stage, overall stage, treatment type, histopathologic subtype, and presence of distant metastasis significantly affected survival. On multivariate analysis overall stage alone significantly predicted overall survival. Open vs. endoscopic surgery, total radiation dose, and presence of neck metastasis did not significantly affect survival. Combined modality treatment was associated with higher survival rates than single modality therapy.
Sinonasal sarcoma is a relatively rare malignancy. Lower T and overall stage, lack of distant metastasis, and multimodality therapy were associated with improved survival. Certain histopathologic subtypes were associated with poorer survival.
肉瘤是一组多样的软组织间叶性恶性肿瘤。鼻窦和鼻腔区域是肉瘤相对少见的发病部位。
对1987年至2017年有关鼻窦肉瘤的文献进行回顾性分析。分析了人口统计学、治疗类型、分期和组织病理学类型等数据。采用Kaplan-Meier分析评估和比较生存率。
共确定并分析了198例鼻窦肉瘤病例。诊断时的中位年龄为39岁。总体5年、10年和20年生存率分别为61.3%、58.9%和49.1%，无病5年、10年和20年生存率分别为53.2%、49.1%和38.3%。3.0%的病例在诊断时有淋巴结转移，3.5%的病例有远处转移。单因素分析显示，T分期、总体分期、治疗类型、组织病理学亚型和远处转移的存在对生存率有显著影响。多因素分析显示，仅总体分期可显著预测总生存率。开放手术与内镜手术、总放疗剂量以及颈部转移的存在对生存率无显著影响。综合治疗模式的生存率高于单一治疗模式。
鼻窦肉瘤是一种相对少见的恶性肿瘤。较低的T分期和总体分期、无远处转移以及多模式治疗与生存率提高相关。某些组织病理学亚型与较差的生存率相关。
