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透析充分性评估:超越尿素动力学测量。

Assessment of dialysis adequacy: beyond urea kinetic measurements.

机构信息

Renal Office, Gt Ormond St Hospital for Children NHS Foundation Trust, WC1N 3JH, London, UK.

出版信息

Pediatr Nephrol. 2019 Jan;34(1):61-69. doi: 10.1007/s00467-018-3914-6. Epub 2018 Mar 26.

Abstract

Adequacy of dialysis is a term that has been used for many years based on measurement of small solute clearance using urea and creatinine. This has been shown in some but not all studies in adults to correlate with survival. However, small solute clearance is just one minor part of the effectiveness of dialysis and in fact 'optimum' dialysis, rather than 'adequate' dialysis is what most paediatric nephrologists would want for their patients. Additional ways to assess the success of dialysis in children would include dialysis access complications and longevity, preservation of residual kidney function, body composition, biochemical and haematological control, nutrition and growth, discomfort during the dialysis process and psychosocial adjustment including hospitalisation and school attendance. These criteria need to be balanced against a dialysis programme that has the least possible adverse effects on quality of life.

摘要

透析充分性是一个多年来一直使用的术语,其基于使用尿素和肌酐测量小分子清除率。在一些但不是所有的成人研究中,这已被证明与生存率相关。然而,小分子清除率只是透析有效性的一个次要部分,实际上,儿科肾脏病学家更希望为他们的患者提供“最佳”透析,而不是“充分”透析。评估儿童透析成功的其他方法还包括透析通路并发症和寿命、残余肾功能的保留、身体成分、生化和血液学控制、营养和生长、透析过程中的不适以及包括住院和上学在内的社会心理调整。这些标准需要与对生活质量影响最小的透析方案相平衡。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ebc2/6244854/cd0e384e0d4a/467_2018_3914_Fig1_HTML.jpg

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