Department of Biology, Colorado State University, Fort Collins, CO 80523, USA; Cell and Molecular Biology Program, Colorado State University, Fort Collins, CO 80523, USA.
Department of Biology, Colorado State University, Fort Collins, CO 80523, USA.
Dev Cell. 2018 Mar 26;44(6):657-658. doi: 10.1016/j.devcel.2018.03.006.
piRNAs are known to silence transposable elements, but not all piRNAs match transposon sequences. Recent studies from Shen et al. (2018) and Zhang et al. (2018) identify rules for piRNA target recognition in Caenorhabditis elegans. Permissive pairing rules allow targeting of essentially all germline mRNAs, while protective mechanisms prevent silencing self-genes.
piRNAs 被认为可以使转座元件沉默，但并非所有 piRNAs 都与转座子序列匹配。最近 Shen 等人（2018 年）和 Zhang 等人（2018 年）的研究确定了秀丽隐杆线虫中 piRNA 靶标识别的规则。允许配对的规则允许靶向几乎所有的生殖系 mRNA，而保护机制则防止沉默自身基因。
