自 2013 年以来，不断出现并扩大的分支导致中国持续爆发柯萨奇病毒 A6 相关手足口病。
An emerging and expanding clade accounts for the persistent outbreak of Coxsackievirus A6-associated hand, foot, and mouth disease in China since 2013.
机构信息
Xiamen Center for Disease Control and Prevention, Shengguang Rd., Jimei District, Xiamen, China.
State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, Xiamen University, Xiang'an Campus of Xiamen University, South Xiang'an Rd., Xiamen, China; National Institute of Diagnostics and Vaccine Development in Infectious Diseases, Xiamen University, Xiang'an Campus of Xiamen University, South Xiang'an Rd., Xiamen, China; School of Public Health, Xiamen University, Xiang'an Campus of Xiamen University, South Xiang'an Rd., Xiamen, China.
出版信息
Virology. 2018 May;518:328-334. doi: 10.1016/j.virol.2018.03.012. Epub 2018 Mar 26.
Enterovirus (EV)-A71 and Coxsackievirus (CV)-A16 have historically been the major pathogens of hand, foot, and mouth disease (HMFD) in China; however, CV-A6， which had previously received little attention, became the predominant pathogen in 2013, and has remained one of the common pathogens since then. In this work, we conducted a molecular epidemiology study of CV-A6-associated HFMD in Xiamen from 2009 to 2015. The data showed CV-A6 pandemics had a certain periodicity rather than occurring randomly. Evolution analysis based on near-complete VP1 nucleotide sequences showed subgenotype D5 lineage 4 strains account for the persistent outbreak of CV-A6-associated HFMD in China since 2013. Alignment analysis revealed eight candidate amino acid substitutions in VP1, which may provide useful information for the research of CV-A6 virulence enhancement. This study contributed to elucidating the circulation patterns and genetic characteristics of CV-A6 in China; however, further surveillance and intervention in CV-A6 epidemics is recommended.
肠道病毒 A71 型（EV-A71）和柯萨奇病毒 A16 型（CV-A16）历来是中国手足口病（HFMD）的主要病原体；然而，此前关注度较低的 CV-A6 型于 2013 年成为主要病原体，此后一直是常见病原体之一。本研究对 2009 年至 2015 年厦门地区 CV-A6 相关 HFMD 进行了分子流行病学研究。结果表明，CV-A6 流行具有一定的周期性，而不是随机发生的。基于 VP1 近全长核苷酸序列的进化分析表明，D5 亚谱系 4 株系是中国 2013 年以来持续暴发 CV-A6 相关 HFMD 的原因。序列比对分析显示 VP1 中有 8 个候选氨基酸取代，可能为 CV-A6 毒力增强的研究提供有用信息。本研究有助于阐明中国 CV-A6 的流行模式和遗传特征；然而，建议进一步监测和干预 CV-A6 流行。
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