微塑料对斑马鱼（Danio rerio）体内镉积累和慢性毒性效应的影响。
Influence of microplastics on the accumulation and chronic toxic effects of cadmium in zebrafish (Danio rerio).
机构信息
State Key Laboratory of Pollution Control and Resource Reuse, School of the Environment, Nanjing University, Nanjing, Jiangsu 210023, China.
State Key Laboratory of Pollution Control and Resource Reuse, School of the Environment, Nanjing University, Nanjing, Jiangsu 210023, China.
出版信息
Chemosphere. 2018 Jul;202:514-520. doi: 10.1016/j.chemosphere.2018.03.145. Epub 2018 Mar 22.
As the accumulation of microplastics (MPs) in the environment continues to rise, more concerns focus on the health risk of combined exposure to MPs and other contaminants. The aim of this study is to investigate the influences of MPs on the tissue-accumulation of cadmium (Cd) in zebrafish and explore the related chronic toxic effects induced by combined exposure of Cd and MPs. After co-exposure to MPs and Cd for 3 weeks, 20 and 200 μg/L MPs increased the accumulation of Cd in zebrafish livers (46% and 184%), guts (10% and 25%) and gills (9% and 46%). The Cd accumulation was gill > gut > liver. Comprehensive analyzes of biochemical biomarkers, histopathological observation and functional gene expression firstly demonstrated that the presence of MPs enhanced the toxicity of Cd on zebrafish and the combined exposure caused oxidative damage and inflammation in zebrafish tissues. Collectively, our results highlight the chronic effects of combined exposure to MPs and heavy metals.
随着环境中微塑料（MPs）的积累不断增加，人们越来越关注 MPs 与其他污染物联合暴露对健康的风险。本研究旨在探讨 MPs 对斑马鱼组织中镉（Cd）积累的影响，并探索 Cd 和 MPs 联合暴露所引起的相关慢性毒性效应。在 MPs 和 Cd 共同暴露 3 周后，20 和 200μg/L MPs 分别使斑马鱼肝、肠和鳃中 Cd 的积累增加了 46%和 184%、10%和 25%、9%和 46%。Cd 的积累呈现出鳃＞肠＞肝的特征。综合生物化学标志物、组织病理学观察和功能基因表达分析结果，首次证明 MPs 的存在增强了 Cd 对斑马鱼的毒性，并且联合暴露导致了斑马鱼组织的氧化损伤和炎症。总之，我们的研究结果强调了 MPs 和重金属联合暴露的慢性效应。
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