State Key Laboratory of Pollution Control and Resource Reuse, School of the Environment, Nanjing University , Nanjing, Jiangsu 210023, China.
Jiangsu Key Lab Environmental Change & Ecological Construct, School of Geography Science, Nanjing Normal University , Nanjing, Jiangsu 210023, China.
Environ Sci Technol. 2016 Apr 5;50(7):4054-60. doi: 10.1021/acs.est.6b00183. Epub 2016 Mar 17.
Microplastics have become emerging contaminants, causing widespread concern about their potential toxic effects. In this study, the uptake and tissue accumulation of polystyrene microplastics (PS-MPs) in zebrafish were detected, and the toxic effects in liver were investigated. The results showed that after 7 days of exposure, 5 μm diameter MPs accumulated in fish gills, liver, and gut, while 20 μm diameter MPs accumulated only in fish gills and gut. Histopathological analysis showed that both 5 μm and 70 nm PS-MPs caused inflammation and lipid accumulation in fish liver. PS-MPs also induced significantly increased activities of superoxide dismutase and catalase, indicating that oxidative stress was induced after treatment with MPs. In addition, metabolomic analysis suggested that exposure to MPs induced alterations of metabolic profiles in fish liver and disturbed the lipid and energy metabolism. These findings provide new insights into the toxic effects of MPs on fish.
微塑料已成为新兴污染物，其潜在的毒性作用引起了广泛关注。在这项研究中，检测了斑马鱼对聚苯乙烯微塑料（PS-MPs）的摄取和组织积累，并研究了其对肝脏的毒性作用。结果表明，暴露 7 天后，5μm 直径的 MPs 积累在鱼鳃、肝脏和肠道中，而 20μm 直径的 MPs 仅积累在鱼鳃和肠道中。组织病理学分析表明，5μm 和 70nm PS-MPs 均导致鱼肝脏炎症和脂质积累。PS-MPs 还显著诱导超氧化物歧化酶和过氧化氢酶活性增加，表明 MPs 处理后诱导了氧化应激。此外，代谢组学分析表明，暴露于 MPs 会引起鱼肝脏代谢谱的改变，并扰乱脂质和能量代谢。这些发现为 MPs 对鱼类的毒性作用提供了新的见解。
