a Department of Nephrology , Shandong University Qilu Hospital , Jinan , P. R. China.
b Xiying Town Hospital , Licheng District , Jinan , P. R. China.
Ren Fail. 2018 Nov;40(1):183-186. doi: 10.1080/0886022X.2018.1455586.
In chronic kidney disease (CKD), endothelin-1 (ET-1) always increases and there are changes in cardiac ultrasonography. In the present study, we aimed at investigating the role of serum ET-1 in predicting cardiac complications in patients with CKD.
The level of serum ET-1 was measured by enzyme-linked immunosorbent assay (ELISA) and cardiac ultrasonography was performed in enrolled patients. Indexes of heart failure, such as left ventricular mass index, interventricular septum thickness and left ventricular end diastolic diameter, were measured in patients with CKD.
In the present study, we found that the level of serum ET-1 was significantly correlated with left ventricular mass index, interventricular septum thickness and left ventricular end diastolic diameter (p < .001) in non-dialysis patients with CKD.
The results of the present study indicated that the level of serum ET-1 is closely related to the cardiac complications of CKD and is a useful predictor of cardiac complication.
在慢性肾脏病（CKD）中，内皮素-1（ET-1）总是增加，并且心脏超声检查也会发生变化。在本研究中，我们旨在研究血清 ET-1 在预测 CKD 患者心脏并发症中的作用。
通过酶联免疫吸附试验（ELISA）测量血清 ET-1 水平，并对入组患者进行心脏超声检查。在 CKD 患者中测量心力衰竭的指标，如左心室质量指数、室间隔厚度和左心室舒张末期直径。
本研究发现，非透析 CKD 患者的血清 ET-1 水平与左心室质量指数、室间隔厚度和左心室舒张末期直径显著相关（p <.001）。
本研究结果表明，血清 ET-1 水平与 CKD 的心脏并发症密切相关，是心脏并发症的有用预测指标。
