Division of Urology, Department of Surgery, Taoyuan General Hospital, Ministry of Health and Welfare, Taoyuan, Taiwan.
Department of Medicine, National Yang-Ming University, Taipei, Taiwan.
BMC Pregnancy Childbirth. 2018 Mar 27;18(1):79. doi: 10.1186/s12884-018-1692-6.
Urinary tract infections (UTIs) are among the most common bacterial infections in pregnant women due to anatomic and physiologic changes in the female urinary tract during pregnancy, and antepartum UTIs can cause adverse pregnancy outcomes that may induce mental stress. There have only been a few studies, however, investigating antepartum UTIs and mental stress. As such, the present study was conducted in order to investigate the association between antepartum UTIs and postpartum depression (PPD).
We used data from the 2000-2013 National Health Insurance Research Database (NHIRD) of Taiwan. Data regarding a total of 55,087 singleton pregnancies was utilized, including data regarding 406 women who were newly diagnosed with PPD in the first 6 months postpartum. The associations between PPD and antepartum UTIs or other risk factors were examined by multiple logistic regression analysis.
The logistic regression analysis results indicated that PPD was associated with antepartum UTIs (adjusted odds ratio [aOR] 1.27; 95% confidence interval [CI] (1.07-1.65). Furthermore, the risk of PPD was higher in women with an upper antepartum UTI (aOR 2.97 (1.31, 6.77) than in those with a lower antepartum UTI (aOR 1.21 (1.02, 1.58)).
Antepartum UTIs, particularly upper antepartum UTIs, are significantly associated with PPD. This information may encourage physicians to pay greater attention to the mental health of women who have suffered upper UTIs during their pregnancies.
由于女性在怀孕期间尿路解剖和生理发生变化，尿路感染（UTI）是孕妇中最常见的细菌感染之一，产前 UTI 可导致不良的妊娠结局，可能引起精神压力。然而，仅有少数研究调查产前 UTI 和精神压力。因此，本研究旨在探讨产前 UTI 与产后抑郁症（PPD）之间的关系。
我们使用了来自台湾 2000-2013 年国家健康保险研究数据库（NHIRD）的数据。该数据共包括 55087 例单胎妊娠，其中包括 406 例在产后 6 个月内新诊断为 PPD 的患者。采用多因素逻辑回归分析探讨 PPD 与产前 UTI 或其他危险因素之间的关系。
逻辑回归分析结果表明，PPD 与产前 UTI 相关（调整后的优势比[aOR] 1.27；95%置信区间[CI]（1.07-1.65）。此外，与下尿路感染相比，上尿路感染患者发生 PPD 的风险更高[aOR 2.97（1.31,6.77）比 aOR 1.21（1.02,1.58）]。
产前 UTI，特别是上尿路感染，与 PPD 显著相关。这些信息可能会鼓励医生更加关注患有上尿路感染的孕妇的心理健康。
