Division of Urology, Department of Surgery, Taoyuan General Hospital, Ministry of Health and Welfare, Taoyuan 330, Taiwan.
Department of Emergency Medicine, China Medical University Hospital, Taichung 404, Taiwan.
Int J Environ Res Public Health. 2021 Jul 5;18(13):7211. doi: 10.3390/ijerph18137211.
Postpartum depression (PPD) is associated with negative physical and mental health outcomes for the mother and infant. Women often experience elevated symptoms of PPD, and the incidence of PPD has increased in recent years. There were lack of studies to investigate the effects of medications during pregnancy. Herein, we focused on the most common obstetric medical therapies used in labor and determined whether the medical therapies cause mental stress in pregnant women. This 14-year retrospective population-based nationwide study was based on the National Health Insurance Research Database. Univariate and multivariate logistic regression analyses were used to evaluate unadjusted and adjusted odds ratios and 95% confidence intervals for each tocolytic and uterotonic treatments during pregnancy and common medical illnesses. In comparing the effects of tocolytic and uterotonic medications on maternal PPD, tocolysis with the injection form of ritodrine resulted in a significantly higher risk of PPD based on multivariate analysis. This study supports existing research demonstrating an association between tocolysis with ritodrine and PPD. Ritodrine treatment for preterm labor was a significant risk factor for PPD, especially the injection form. This information provides obstetricians and health policy providers to pay attention to maternal mental health outcomes among high-risk pregnant women.
产后抑郁症（PPD）会对母亲和婴儿的身心健康产生负面影响。女性经常会出现 PPD 症状加重的情况，近年来 PPD 的发病率也有所上升。目前缺乏研究来探讨怀孕期间药物治疗的效果。在此，我们重点研究了分娩中最常用的产科医疗疗法，并确定这些医疗疗法是否会给孕妇带来精神压力。这项为期 14 年的基于人群的全国性回顾性研究基于国家健康保险研究数据库。采用单变量和多变量逻辑回归分析评估了未调整和调整后的比值比及其 95%置信区间，以评估妊娠期间使用的每种保胎和子宫收缩药物以及常见内科疾病的比值比及其 95%置信区间。在比较保胎和子宫收缩药物对产妇 PPD 的影响时，多变量分析显示，利托君的注射剂型与 PPD 风险显著增加相关。这项研究支持现有的研究结果，表明利托君的保胎治疗与 PPD 之间存在关联。治疗早产的利托君是 PPD 的一个显著危险因素，尤其是注射剂型。这些信息为产科医生和医疗政策制定者提供了依据，以便关注高危孕妇的产妇心理健康结局。
