Wald David S, Bestwick Jonathan P
Professor of Cardiology.
Lecturer in Medical Statistics, Wolfson Institute of Preventive Medicine, London, UK.
Interv Cardiol. 2015 Mar;10(1):32-34. doi: 10.15420/icr.2015.10.1.32.
Randomised trials show a benefit of preventive (non-infarct artery) percutaneous coronary intervention in patients with acute ST elevation myocardial infarction, but non-randomised studies do not. The evidence on each is quantified and assessed. The primacy of randomised trials reveals the danger of using non-randomised studies that can, as in this case, give the wrong answer.
随机试验表明,对于急性ST段抬高型心肌梗死患者,预防性(非梗死相关动脉)经皮冠状动脉介入治疗有益,但非随机研究则未显示出此益处。对二者的证据进行了量化和评估。随机试验的首要地位揭示了使用非随机研究的风险,就像在这个案例中,非随机研究可能会给出错误答案。