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Polymer-free Drug-Coated Coronary Stents in Patients at High Bleeding Risk.高出血风险患者的无聚合物涂层药物洗脱冠状动脉支架。
N Engl J Med. 2015 Nov 19;373(21):2038-47. doi: 10.1056/NEJMoa1503943. Epub 2015 Oct 14.
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Stopping or continuing clopidogrel 12 months after drug-eluting stent placement: the OPTIDUAL randomized trial.氯吡格雷在药物洗脱支架置入 12 个月后停药或继续治疗：OPTIDUAL 随机试验
Eur Heart J. 2016 Jan 21;37(4):365-74. doi: 10.1093/eurheartj/ehv481. Epub 2015 Sep 12.
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2015 ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation: Task Force for the Management of Acute Coronary Syndromes in Patients Presenting without Persistent ST-Segment Elevation of the European Society of Cardiology (ESC).2015年欧洲心脏病学会（ESC）非持续性ST段抬高型急性冠脉综合征患者管理指南：欧洲心脏病学会（ESC）非持续性ST段抬高型急性冠脉综合征患者管理工作组
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Optimal duration of dual antiplatelet therapy after percutaneous coronary intervention with drug eluting stents: meta-analysis of randomised controlled trials.药物洗脱支架经皮冠状动脉介入治疗后双重抗血小板治疗的最佳持续时间：随机对照试验的荟萃分析
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Long-term use of ticagrelor in patients with prior myocardial infarction.既往心肌梗死患者中长期使用替格瑞洛。
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Zotarolimus-eluting versus bare-metal stents in uncertain drug-eluting stent candidates.在不确定是否适合药物洗脱支架的患者中，使用佐他莫司洗脱支架与裸金属支架。
J Am Coll Cardiol. 2015 Mar 3;65(8):805-815. doi: 10.1016/j.jacc.2014.11.053.
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ISAR-SAFE: a randomized, double-blind, placebo-controlled trial of 6 vs. 12 months of clopidogrel therapy after drug-eluting stenting.ISAR-SAFE 研究：药物洗脱支架置入后氯吡格雷治疗 6 个月与 12 个月的随机、双盲、安慰剂对照临床试验
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Twelve or 30 months of dual antiplatelet therapy after drug-eluting stents.药物洗脱支架置入术后12个月或30个月的双联抗血小板治疗。
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Second-generation drug-eluting stent implantation followed by 6- versus 12-month dual antiplatelet therapy: the SECURITY randomized clinical trial.第二代药物洗脱支架置入后 6 个月与 12 个月双联抗血小板治疗：SECURITY 随机临床试验。
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药物洗脱支架植入术后的双重抗血小板治疗

Dual Antiplatelet Therapy After Drug-eluting Stent Implantation.

作者信息

Magnani Giulia, Valgimigli Marco

机构信息

Bern University Hospital, Inselspital, Bern, Switzerland.

出版信息

Interv Cardiol. 2016 May;11(1):51-53. doi: 10.15420/icr.2015:17:2.

DOI:10.15420/icr.2015:17:2
PMID:29588706
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5808681/
Abstract

The current guidelines for percutaneous coronary intervention use recommend dual antiplatelet therapy (DAPT) with aspirin and a P2Y12 inhibitor after drug eluting stent (DES) implantation. The optimal duration of DAPT is however area of debate. Recent clinical trials and meta-analyses suggest that the choice of DAPT duration should be tailored individually, based on the balance between ischemic and bleeding risk carried by the patient.

摘要

当前经皮冠状动脉介入治疗的使用指南建议，在药物洗脱支架（DES）植入后，采用阿司匹林和P2Y12抑制剂进行双联抗血小板治疗（DAPT）。然而，DAPT的最佳持续时间仍存在争议。最近的临床试验和荟萃分析表明，DAPT持续时间的选择应根据患者缺血和出血风险之间的平衡进行个体化调整。