FAME试验：对临床决策的影响。
The FAME Trials: Impact on Clinical Decision Making.
作者信息
Heyndrickx Guy R, Tóth Gábor G
机构信息
Cardiovascular Center Aalst, OLV-Clinic, Aalst, Belgium.
University Heart Center, Medical University of Graz, Graz, Austria.
出版信息
Interv Cardiol. 2016 Oct;11(2):116-119. doi: 10.15420/icr.2016:14:3.
Abstract
Careful and stepwise evaluation of the fractional flow reserve (FFR) index has been performed over the years, culminating in the landmark Fractional Flow Reserve Versus Angiography for Multivessel Evaluation (FAME) and Fractional Flow Reserve-Guided Percutaneous Coronary Intervention Plus Optimal Medical Treatment Versus Optimal Medical Treatment Alone in Patients with Stable Coronary Artery Disease (FAME II) trials. Findings from these studies demonstrated unequivocally the overall inadequacy of angiography versus FFR to correctly assess stenosis severity. Thus, proof of concept and clinical applicability was established beyond debate and will be discussed here.
摘要
多年来，人们对血流储备分数（FFR）指数进行了细致且逐步的评估，最终促成了具有里程碑意义的多支血管评估血流储备分数与血管造影术（FAME）试验以及稳定冠状动脉疾病患者血流储备分数指导的经皮冠状动脉介入治疗加优化药物治疗与单纯优化药物治疗对比试验（FAME II）。这些研究结果明确表明，与FFR相比，血管造影术在正确评估狭窄严重程度方面总体存在不足。因此，概念验证和临床适用性已无可争议地确立，本文将对此进行讨论。
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