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采用顺行和逆行技术实现双慢性完全闭塞再通以及使用新型可生物降解聚合物药物洗脱支架

Double Chronic Total Occlusion Recanalisation with Antegrade and Retrograde Techniques and the Use of a Novel Drug-eluting Stent with Biodegradable Polymer.

作者信息

Konstantinidis Nikolaos V, Sianos Georgios

机构信息

1st Department of Cardiology, AHEPA University Hospital, Thessaloniki, Greece.

出版信息

Interv Cardiol. 2013 Mar;8(1):46-49. doi: 10.15420/icr.2013.8.1.46.

DOI:10.15420/icr.2013.8.1.46
PMID:29588750
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5808694/
Abstract

Percutaneous recanalisation of coronary chronic total occlusions (CTOs) has proved an efficient and safe treatment option with steadily ascending success rates, especially since the advent and constant refinement of the retrograde approach. Uptake remains low, even though experienced operators have in the last five years reached an unprecedented maturity level, producing success rates in the range of 90 %, clearly comparable to non-occlusive coronary artery disease treatment. Antegrade and retrograde techniques are currently considered complementary components of a CTO procedure, rather than discrete treatment strategies. We report on the case of a successful CTO recanalisation procedure on a young patient with two chronically occluded coronary arteries and a large ischaemic burden. Both CTOs were addressed in the same session employing a range of dedicated CTO recanalisation techniques, without compromising on safety issues related to contrast dye consumption and radiation exposure. A novel drug-eluting stent (DES) with biodegradable polymer was used to treat the lesions.

摘要

经皮冠状动脉慢性完全闭塞病变(CTO)再通已被证明是一种有效且安全的治疗选择,成功率稳步上升,特别是自逆向技术问世并不断完善以来。尽管经验丰富的术者在过去五年已达到前所未有的成熟水平,成功率达到90%左右,可与非闭塞性冠状动脉疾病治疗相媲美,但该技术的应用率仍然较低。目前,正向和逆向技术被视为CTO手术的互补组成部分,而非独立的治疗策略。我们报告了一例成功的CTO再通手术病例,患者为年轻男性,有两条冠状动脉慢性闭塞且缺血负荷大。在同一次手术中采用了一系列专门的CTO再通技术处理两条CTO病变,同时不影响与造影剂用量和辐射暴露相关的安全性问题。使用了一种新型的可生物降解聚合物药物洗脱支架(DES)来治疗病变。

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本文引用的文献

1
Five-year outcomes in patients with chronic total coronary occlusion treated with drug-eluting vs bare-metal stents: a case-control study.药物洗脱支架与金属裸支架治疗慢性完全闭塞性冠状动脉病变患者的 5 年结果:病例对照研究。
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Short and long term comparison (24 months) of an alternative sirolimus-coated stent with bioabsorbable polymer and a bare metal stent of similar design in chronic coronary occlusions: the CORACTO trial.短期和长期对比(24 个月):一种新型西罗莫司涂层、带生物可吸收聚合物的支架与设计相似的金属裸支架在慢性冠状动脉闭塞中的应用:CORACTO 试验。
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CTO PCI at the crossroads.慢性完全闭塞病变经皮冠状动脉介入治疗处于十字路口。
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Efficacy and safety of drug-eluting stents in chronic total coronary occlusion recanalization: a systematic review and meta-analysis.药物洗脱支架治疗慢性完全闭塞性冠状动脉再通的疗效和安全性:系统评价和荟萃分析。
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Retrograde percutaneous recanalization of chronic total occlusion of the coronary arteries: procedural outcomes and predictors of success in contemporary practice.经皮逆行冠状动脉慢性完全闭塞再通术:当代实践中的程序结局和成功预测因素。
Circ Cardiovasc Interv. 2009 Apr;2(2):124-32. doi: 10.1161/CIRCINTERVENTIONS.108.838862. Epub 2009 Feb 20.
7
Clinical and angiographic outcomes with sirolimus-eluting stents in total coronary occlusions: the ACROSS/TOSCA-4 (Approaches to Chronic Occlusions With Sirolimus-Eluting Stents/Total Occlusion Study of Coronary Arteries-4) trial.在完全闭塞病变中应用西罗莫司洗脱支架的临床和血管造影结果:ACROSS/TOSCA-4 试验(西罗莫司洗脱支架治疗慢性闭塞病变/冠状动脉完全闭塞研究 4)。
JACC Cardiovasc Interv. 2009 Feb;2(2):97-106. doi: 10.1016/j.jcin.2008.10.013.
8
European experience with the retrograde approach for the recanalisation of coronary artery chronic total occlusions. A report on behalf of the euroCTO club.
EuroIntervention. 2008 May;4(1):84-92. doi: 10.4244/eijv4i1a15.
9
Optimal medical therapy with or without percutaneous coronary intervention to reduce ischemic burden: results from the Clinical Outcomes Utilizing Revascularization and Aggressive Drug Evaluation (COURAGE) trial nuclear substudy.采用或不采用经皮冠状动脉介入治疗的优化药物治疗以减轻缺血负担:来自利用血运重建和强化药物评估的临床结果(COURAGE)试验核子亚研究的结果
Circulation. 2008 Mar 11;117(10):1283-91. doi: 10.1161/CIRCULATIONAHA.107.743963. Epub 2008 Feb 11.
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New concept for CTO recanalization using controlled antegrade and retrograde subintimal tracking: the CART technique.使用可控顺行和逆行内膜下寻径开通慢性完全闭塞病变的新概念:CART技术。
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