Ota K, Kimura T, Ito M, Inoue M, Shoji M, Shinoda S, Nagashima M, Matsui K, Iitake K, Yoshinaga K
Second Department of Internal Medicine, Tohoku University, School of Medicine, Sendai, Japan.
Acta Endocrinol (Copenh). 1987 Oct;116(2):235-40. doi: 10.1530/acta.0.1160235.
In order to study the effect of atrial tachycardia on the release of atrial natriuretic peptide (ANP), AVP, and methionine enkephalin (M-Enk), plasma concentrations of these peptides in the right ventricle were determined in patients with various arrhythmias (N = 10) during cardiac catheterization and incremental atrial pacing. Each pacing (100 per min, the maximum rate for 1:1 atrioventricular conduction, and 200 per min) lasted 4 to 5 min. Plasma ANP was significantly increased from 53.1 +/- 12.2 in the resting condition to 168.9 +/- 59.9 pmol/l at a pacing rate of 200 beats per min (P less than 0.05); plasma AVP tended to decrease, but not significantly, and plasma M-Enk did not change at all. Pulse pressure in the right atrium (PPRA) and mean right atrial pressure (MRAP) tended to increase during the pacing, and at the rate of 200 beats per min PPRA was significantly higher than at the rate of 100 beats per min. Mean arterial blood pressure, plasma osmolality, and plasma sodium and potassium concentrations did not change significantly. There were significant correlations between plasma ANP and PPRA, MRAP and heart rate. These results indicate that atrial pacing stimulates ANP release with a rise in right atrial pressure, but does not influence M-Enk and AVP releases.
为研究房性心动过速对心房利钠肽（ANP）、血管加压素（AVP）和甲硫氨酸脑啡肽（M-Enk）释放的影响，在心脏导管插入术和递增性心房起搏过程中，测定了10例患有各种心律失常患者右心室中这些肽类的血浆浓度。每次起搏（每分钟100次，1:1房室传导的最大速率，以及每分钟200次）持续4至5分钟。血浆ANP在静息状态下为53.1±12.2，在起搏速率为每分钟200次时显著升高至168.9±59.9 pmol/l（P<0.05）；血浆AVP有下降趋势，但不显著，血浆M-Enk则完全没有变化。起搏过程中右心房脉压（PPRA）和平均右心房压（MRAP）有升高趋势，在每分钟200次的速率时，PPRA显著高于每分钟100次的速率。平均动脉血压、血浆渗透压以及血浆钠和钾浓度均无显著变化。血浆ANP与PPRA、MRAP和心率之间存在显著相关性。这些结果表明，心房起搏通过右心房压力升高刺激ANP释放，但不影响M-Enk和AVP的释放。
