综述：麦角硫因和卵硫醇的生物合成，天然产物生物合成中前所未有的转硫策略
Mini-Review: Ergothioneine and Ovothiol Biosyntheses, an Unprecedented Trans-Sulfur Strategy in Natural Product Biosynthesis.
作者信息
Naowarojna Nathchar, Cheng Ronghai, Chen Li, Quill Melissa, Xu Meiling, Zhao Changming, Liu Pinghua
机构信息
Department of Chemistry , Boston University , Boston , Massachusetts 02215 , United States.
Key Laboratory of Combinatory Biosynthesis and Drug Discovery, Ministry of Education, School of Pharmaceutical Sciences , Wuhan University , Wuhan , Hubei 430072 , People's Republic of China.
出版信息
Biochemistry. 2018 Jun 19;57(24):3309-3325. doi: 10.1021/acs.biochem.8b00239. Epub 2018 Apr 6.
Abstract
As one of the most abundant elements on earth, sulfur is part of many small molecular metabolites and is key to their biological activities. Over the past few decades, some general strategies have been discovered for the incorporation of sulfur into natural products. In this review, we summarize recent efforts in elucidating the biosynthetic details for two sulfur-containing metabolites, ergothioneine and ovothiol. Their biosyntheses involve an unprecedented trans-sulfur strategy, a combination of a mononuclear non-heme iron enzyme-catalyzed oxidative C-S bond formation reaction and a PLP enzyme-mediated C-S lyase reaction.
摘要
作为地球上含量最丰富的元素之一，硫是许多小分子代谢物的组成部分，并且是其生物活性的关键。在过去几十年中，人们发现了一些将硫掺入天然产物的通用策略。在本综述中，我们总结了最近在阐明两种含硫代谢物麦角硫因和卵硫醇生物合成细节方面所做的努力。它们的生物合成涉及一种前所未有的转硫策略，即单核非血红素铁酶催化的氧化碳 - 硫键形成反应与磷酸吡哆醛（PLP）酶介导的碳 - 硫裂解反应的结合。
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