Proteoforms as the next proteomics currency.
作者信息
Smith Lloyd M, Kelleher Neil L
机构信息
Department of Chemistry, University of Wisconsin, 1101 University Avenue, Madison, WI 53706-1396, USA.
Departments of Chemistry and Molecular Biosciences and Feinberg School of Medicine, Northwestern University, Evanston, IL 60208, USA.
出版信息
Science. 2018 Mar 9;359(6380):1106-1107. doi: 10.1126/science.aat1884. Epub 2018 Mar 8.
Abstract
摘要
相似文献
1
Proteoforms as the next proteomics currency.
Science. 2018 Mar 9;359(6380):1106-1107. doi: 10.1126/science.aat1884. Epub 2018 Mar 8.
2
Deducing the presence of proteins and proteoforms in quantitative proteomics.
Nat Commun. 2018 Jun 13;9(1):2320. doi: 10.1038/s41467-018-04411-5.
3
The application of terminomics for the identification of protein start sites and proteoforms in bacteria.
Proteomics. 2016 Jan;16(2):257-72. doi: 10.1002/pmic.201500319. Epub 2015 Nov 23.
4
The Blood Proteoform Atlas: A reference map of proteoforms in human hematopoietic cells.
Science. 2022 Jan 28;375(6579):411-418. doi: 10.1126/science.aaz5284. Epub 2022 Jan 27.
5
Profiling proteoforms: promising follow-up of proteomics for biomarker discovery.
Expert Rev Proteomics. 2014 Feb;11(1):121-9. doi: 10.1586/14789450.2014.878652.
6
Genomics. Molecular prodigality.
Science. 2003 Feb 21;299(5610):1189-90. doi: 10.1126/science.1080010.
7
SpliceProt: a protein sequence repository of predicted human splice variants.
Proteomics. 2014 Feb;14(2-3):181-5. doi: 10.1002/pmic.201300078.
8
A question of form.
Nature. 2003 Mar 20;422(6929):341. doi: 10.1038/422341b.
9
The use of proteases complementary to trypsin to probe isoforms and modifications.
Proteomics. 2016 Mar;16(5):715-28. doi: 10.1002/pmic.201500379.
10
Absolute quantitation of protein posttranslational modification isoform.
Methods Mol Biol. 2015;1306:105-19. doi: 10.1007/978-1-4939-2648-0_8.
引用本文的文献
1
Structural Heterogeneity of Proteoform-Ligand Complexes in Adenosine Monophosphate-Activated Protein Kinase Uncovered by Integrated Top-Down Mass Spectrometry.
J Am Chem Soc. 2025 Aug 14. doi: 10.1021/jacs.5c06950.
2
Mass spectrometry-based top-down proteomics for proteoform profiling of protein coronas.
Nat Protoc. 2025 Aug 5. doi: 10.1038/s41596-025-01229-6.
3
From Solution to Gas Phase: Revealing Ligand-Dependent Conformations of Ribonuclease A with Tandem-Trapped Ion Mobility Spectrometry.
JACS Au. 2025 Jun 23;5(7):3219-3227. doi: 10.1021/jacsau.5c00405. eCollection 2025 Jul 28.
4
Activated GDF11/8 subforms predict cardiovascular events and mortality in humans.
Nat Commun. 2025 Jul 15;16(1):6534. doi: 10.1038/s41467-025-61815-w.
5
Improving accuracy and reproducibility of mass spectrometry characterization of protein coronas on nanoparticles.
Nat Protoc. 2025 Jun 11. doi: 10.1038/s41596-025-01204-1.
6
Proteoform profiling of endogenous single cells from rat hippocampus at scale.
Nat Biotechnol. 2025 May 15. doi: 10.1038/s41587-025-02669-x.
7
Time-lapse tryptic digestion: a proteomic approach to improve sequence coverage of extracellular matrix proteins.
bioRxiv. 2025 Mar 28:2025.03.26.645502. doi: 10.1101/2025.03.26.645502.
8
StageTip: a little giant unveiling the potential of mass spectrometry-based proteomics.
Anal Sci. 2025 May;41(5):667-675. doi: 10.1007/s44211-025-00749-1. Epub 2025 Mar 26.
9
Top-Down Proteomic Profiling of Protein Corona by High-Throughput Capillary Isoelectric Focusing-Mass Spectrometry.
J Am Soc Mass Spectrom. 2025 Apr 2;36(4):778-786. doi: 10.1021/jasms.4c00463. Epub 2025 Mar 2.
10
Functional proteoform group deconvolution reveals a broader spectrum of ibrutinib off-targets.
Nat Commun. 2025 Feb 25;16(1):1948. doi: 10.1038/s41467-024-54654-8.
本文引用的文献
1
How many human proteoforms are there?
Nat Chem Biol. 2018 Feb 14;14(3):206-214. doi: 10.1038/nchembio.2576.
2
RNA splicing is a primary link between genetic variation and disease.
Science. 2016 Apr 29;352(6285):600-4. doi: 10.1126/science.aad9417. Epub 2016 Apr 28.
3
Elucidating Proteoform Families from Proteoform Intact-Mass and Lysine-Count Measurements.
J Proteome Res. 2016 Apr 1;15(4):1213-21. doi: 10.1021/acs.jproteome.5b01090. Epub 2016 Mar 16.
4
Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.
Cell. 2016 Feb 11;164(4):805-17. doi: 10.1016/j.cell.2016.01.029.
5
Mass spectrometric analysis of histone proteoforms.
Annu Rev Anal Chem (Palo Alto Calif). 2014;7(1):113-28. doi: 10.1146/annurev-anchem-071213-015959. Epub 2014 Jun 2.
6
An approach to correlate tandem mass spectral data of peptides with amino acid sequences in a protein database.
J Am Soc Mass Spectrom. 1994 Nov;5(11):976-89. doi: 10.1016/1044-0305(94)80016-2.
7
Proteoform: a single term describing protein complexity.
Nat Methods. 2013 Mar;10(3):186-7. doi: 10.1038/nmeth.2369.
8
De novo derivation of proteomes from transcriptomes for transcript and protein identification.
Nat Methods. 2012 Dec;9(12):1207-11. doi: 10.1038/nmeth.2227. Epub 2012 Nov 11.
9
Protein identification using customized protein sequence databases derived from RNA-Seq data.
J Proteome Res. 2012 Feb 3;11(2):1009-17. doi: 10.1021/pr200766z. Epub 2011 Dec 14.
10
Mapping intact protein isoforms in discovery mode using top-down proteomics.
Nature. 2011 Oct 30;480(7376):254-8. doi: 10.1038/nature10575.
Zotero 插件