Chan T B, Eiser N, Shelton D, Rees P J
United Medical, School of Guy's Hospital, London.
Br J Dis Chest. 1987 Jul;81(3):260-7. doi: 10.1016/0007-0971(87)90159-8.
In seven normal subjects and five asthmatics we have compared the effects of inhaled histamine with that of betahistine (a relatively selective H1-receptor agonist) and that of impromidine (a relatively H2-receptor agonist) on pulmonary epithelial permeability, as measured by the half-time clearance from lung to blood of inhaled 99mTc-DTPA (t1/2LB). Both histamine and betahistine produced statistically significant falls in baseline t1/2LB and peak expiratory flow rate, while impromidine produced no significant effects on either parameter. Similar results were obtained in normal subjects and asthmatics alike. In four of the normal subjects, histamine-induced falls in t1/2LB and peak expiratory flow rate were prevented by oral pretreatment with terfenadine 120 mg but not by cimetidine 400 mg. Histamine-induced increases in lung permeability and bronchoconstriction are both mediated via H1-receptors in normal and asthmatic subjects.
在7名正常受试者和5名哮喘患者中，我们比较了吸入组胺、倍他司汀（一种相对选择性的H1受体激动剂）和英普咪定（一种相对的H2受体激动剂）对肺上皮通透性的影响，肺上皮通透性通过吸入的99mTc-DTPA从肺到血液的清除半衰期（t1/2LB）来测量。组胺和倍他司汀均使基线t1/2LB和呼气峰值流速出现统计学上的显著下降，而英普咪定对这两个参数均无显著影响。正常受试者和哮喘患者获得了相似的结果。在4名正常受试者中，口服120 mg特非那定预处理可预防组胺引起的t1/2LB和呼气峰值流速下降，但400 mg西咪替丁则不能。在正常和哮喘受试者中，组胺引起的肺通透性增加和支气管收缩均通过H1受体介导。
