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Gastric mucosal blood flow and acid secretory changes in man with impromidine: a new specific histamine-H2-receptor agonist.用英普咪定（一种新型特异性组胺-H2受体激动剂）对人体胃黏膜血流及胃酸分泌变化的研究
Gut. 1981 Jul;22(7):529-33. doi: 10.1136/gut.22.7.529.
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Gastric secretory studies in humans with impromidine (SK&F 92676)--a specific histamine H2 receptor agonist.使用英普咪定（SK&F 92676）——一种特异性组胺H2受体激动剂，对人体进行胃分泌研究。
Gastroenterology. 1980 Mar;78(3):505-11.
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Cardiovascular studies with impromidine (SK&F 92676), a new very potent and specific histamine H2-receptor agonist.使用新型强效特异性组胺H2受体激动剂英普咪定（SK&F 92676）进行的心血管研究。
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Impromidine (SK&F 92676)--a potent and highly selective histamine H2-receptor agonist in man [proceedings].英普咪定（SK&F 92676）——一种对人体强效且高度选择性的组胺H2受体激动剂[会议论文集]
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Effect of cimetidine on the hepatic extraction of indocyanine green, the portal pressure and the systemic circulation in patients with cirrhosis of the liver.西咪替丁对肝硬化患者肝脏摄取吲哚菁绿、门静脉压力及体循环的影响。
Klin Wochenschr. 1984 Aug 16;62(16):759-64. doi: 10.1007/BF01721773.
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Gastric acid secretion induced by impromidine in the dog and man: analysis of dose-response relationships.在犬和人类中，因英普咪定诱导的胃酸分泌：剂量反应关系分析。
Agents Actions. 1982 Apr;12(1-2):166-7. doi: 10.1007/BF01965133.

本文引用的文献

1
The effect of histamine and histamine antagonists on gastric acid secretion and mucosal blood flow in man.组胺及组胺拮抗剂对人体胃酸分泌和黏膜血流的影响。
Br J Surg. 1980 Apr;67(4):266-8. doi: 10.1002/bjs.1800670412.
2
Gastric secretory studies in humans with impromidine (SK&F 92676)--a specific histamine H2 receptor agonist.使用英普咪定（SK&F 92676）——一种特异性组胺H2受体激动剂，对人体进行胃分泌研究。
Gastroenterology. 1980 Mar;78(3):505-11.
3
Gastric secretion in relation to mucosal blood flow studied by a clearance technic.用清除技术研究胃分泌与粘膜血流的关系。
J Clin Invest. 1966 Jan;45(1):1-13. doi: 10.1172/JCI105313.
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Vacuum aspiration of the uterus in therapeutic abortion.治疗性流产中的子宫真空吸引术。
Br Med J. 1970 May 23;1(5707):456-7. doi: 10.1136/bmj.2.5707.456.
5
Aminopyrine clearance in the damaged gastric mucosa: reconciliation of conflicting data.受损胃黏膜中氨基比林清除率：相互矛盾数据的协调
Gastroenterology. 1973 Sep;65(3):512-4.
6
Definition and antagonism of histamine H 2 -receptors.组胺H2受体的定义与拮抗作用。
Nature. 1972 Apr 21;236(5347):385-90. doi: 10.1038/236385a0.
7
Histamine H1- and H2-receptor vasodilation of canine intestinal circulation.组胺H1和H2受体对犬肠道循环的血管舒张作用。
Am J Physiol. 1977 Sep;233(3):E219-24. doi: 10.1152/ajpendo.1977.233.3.E219.
8
Impromidine (SK&F 92676) is a very potent and specific agonist for histamine H2 receptors.英普咪定（SK&F 92676）是一种效力很强且特异性很高的组胺H2受体激动剂。
Nature. 1978 Nov 23;276(5686):403-5. doi: 10.1038/276403a0.

用英普咪定（一种新型特异性组胺-H2受体激动剂）对人体胃黏膜血流及胃酸分泌变化的研究

Gastric mucosal blood flow and acid secretory changes in man with impromidine: a new specific histamine-H2-receptor agonist.

作者信息

McIsaac R L, Johnston B J, Fielding L P

出版信息

Gut. 1981 Jul;22(7):529-33. doi: 10.1136/gut.22.7.529.

DOI:10.1136/gut.22.7.529
PMID:6455334
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1419320/
Abstract

The effect of impromidine, a new histamine-H2-receptor agonist, on gastric mucosal blood flow (neutral red clearance) and acid secretion was studied in nine volunteers. Impromidine stimulated a dose-dependent increase in neutral red clearance and acid secretion. Simultaneous cimetidine in three doses caused a parallel shift to the right for both acid output and clearance with unchanged maxima compatible with simple surmountable antagonism. There were small cardiovascular changes: an increased heart rate with a decreased diastolic pressure during infusion of impromidine. These changes were antagonised by cimetidine.

摘要

在9名志愿者中研究了新型组胺H2受体激动剂英普咪定对胃黏膜血流（中性红清除率）和胃酸分泌的影响。英普咪定刺激中性红清除率和胃酸分泌呈剂量依赖性增加。同时给予三种剂量的西咪替丁，导致胃酸分泌量和清除率的剂量反应曲线平行右移，最大值不变，符合简单的可克服性拮抗作用。有轻微的心血管变化：输注英普咪定时心率增加，舒张压降低。这些变化被西咪替丁拮抗。