用英普咪定（一种新型特异性组胺-H2受体激动剂）对人体胃黏膜血流及胃酸分泌变化的研究
Gastric mucosal blood flow and acid secretory changes in man with impromidine: a new specific histamine-H2-receptor agonist.
作者信息
McIsaac R L, Johnston B J, Fielding L P
出版信息
Gut. 1981 Jul;22(7):529-33. doi: 10.1136/gut.22.7.529.
Abstract
The effect of impromidine, a new histamine-H2-receptor agonist, on gastric mucosal blood flow (neutral red clearance) and acid secretion was studied in nine volunteers. Impromidine stimulated a dose-dependent increase in neutral red clearance and acid secretion. Simultaneous cimetidine in three doses caused a parallel shift to the right for both acid output and clearance with unchanged maxima compatible with simple surmountable antagonism. There were small cardiovascular changes: an increased heart rate with a decreased diastolic pressure during infusion of impromidine. These changes were antagonised by cimetidine.
摘要
在9名志愿者中研究了新型组胺H2受体激动剂英普咪定对胃黏膜血流（中性红清除率）和胃酸分泌的影响。英普咪定刺激中性红清除率和胃酸分泌呈剂量依赖性增加。同时给予三种剂量的西咪替丁，导致胃酸分泌量和清除率的剂量反应曲线平行右移，最大值不变，符合简单的可克服性拮抗作用。有轻微的心血管变化：输注英普咪定时心率增加，舒张压降低。这些变化被西咪替丁拮抗。
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本文引用的文献
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The effect of histamine and histamine antagonists on gastric acid secretion and mucosal blood flow in man.组胺及组胺拮抗剂对人体胃酸分泌和黏膜血流的影响。
Br J Surg. 1980 Apr;67(4):266-8. doi: 10.1002/bjs.1800670412.
2
Gastric secretory studies in humans with impromidine (SK&F 92676)--a specific histamine H2 receptor agonist.使用英普咪定（SK&F 92676）——一种特异性组胺H2受体激动剂，对人体进行胃分泌研究。
Gastroenterology. 1980 Mar;78(3):505-11.
3
Gastric secretion in relation to mucosal blood flow studied by a clearance technic.用清除技术研究胃分泌与粘膜血流的关系。
J Clin Invest. 1966 Jan;45(1):1-13. doi: 10.1172/JCI105313.
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Aminopyrine clearance in the damaged gastric mucosa: reconciliation of conflicting data.受损胃黏膜中氨基比林清除率：相互矛盾数据的协调
Gastroenterology. 1973 Sep;65(3):512-4.
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Definition and antagonism of histamine H 2 -receptors.组胺H2受体的定义与拮抗作用。
Nature. 1972 Apr 21;236(5347):385-90. doi: 10.1038/236385a0.
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