信号肽肽酶参与丙型肝炎病毒的传播和发病机制
[Signal peptide peptidase participates in propagation and pathogenesis of hepatitis C virus].
作者信息
Okamoto Toru
机构信息
Department of Molecular Virology, Research Institute for Microbial Diseases.
出版信息
Uirusu. 2017;67(1):49-58. doi: 10.2222/jsv.67.49.
PMID:29593153
Abstract
Hepatitis C virus (HCV) is a blood-borne virus and causes chronic infection leading to development of steatosis, cirrhosis and hepatocellular carcinoma. However, molecular mechanisms of induction of liver diseases by HCV infection are still unclear. This review focuses on thevirological significance of processing of HCV core protein by signal peptide peptidase in propagation and pathogenesis of HCV.
摘要
丙型肝炎病毒（HCV）是一种血源性病毒，可导致慢性感染，进而发展为脂肪变性、肝硬化和肝细胞癌。然而，HCV感染诱发肝脏疾病的分子机制仍不清楚。本综述聚焦于信号肽肽酶对HCV核心蛋白的加工在HCV传播和发病机制中的病毒学意义。
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