Moriishi Kohji, Mori Yoshio, Matsuura Yoshiharu
Department of Molecular Virology, Research Institute for Microbial Diseases, Osaka University, 3-1, Yamadaoka, Suita, Osaka 565-0871, Japan.
Uirusu. 2008 Dec;58(2):183-90. doi: 10.2222/jsv.58.183.
Hepatitis C virus (HCV) is a major causative agent of blood-borne hepatitis. Most of the HCV-positive individuals have been chronically infected with the virus for decades, leading to development of steatosis, cirrhosis and ultimately hepatocellular carcinoma. In addition, cryoglobulinemia and type 2 diabetes mellitus are associated with a chronic infection with HCV. Hepatocellular carcinoma induced by HCV infection is not caused by only the repeated inflammations but also the biological activity of HCV proteins. HCV core protein has been reported as a component of the viral nucleocapsid as well as the pathogenic factor that could induce the production of oxidative stress and progression of cell growth. In this review, we summarize the current status of our knowledge regarding to the processing and pathogenicity of HCV core protein.
丙型肝炎病毒（HCV）是血源性肝炎的主要致病因子。大多数HCV阳性个体已被该病毒慢性感染数十年，导致脂肪变性、肝硬化并最终发展为肝细胞癌。此外，冷球蛋白血症和2型糖尿病与HCV慢性感染有关。HCV感染诱发的肝细胞癌不仅是由反复炎症引起的，还与HCV蛋白的生物学活性有关。HCV核心蛋白已被报道为病毒核衣壳的组成成分以及可诱导氧化应激产生和细胞生长进程的致病因子。在本综述中，我们总结了目前关于HCV核心蛋白加工和致病性的知识现状。
