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莫达非尼成瘾:一例合并注意缺陷多动障碍的病例

Modafinil Dependence: A Case with Attention-Deficit/Hyperactivity Disorder.

作者信息

Alacam Huseyin, Basay Omer, Tumkaya Selim, Mart Mehmet, Kar Gokce

机构信息

Department of Psychiatry, Faculty of Medicine, Pamukkale University, Denizli, Turkey.

Department of Child and Adolescent Psychiatry, Faculty of Medicine, Pamukkale University, Denizli, Turkey.

出版信息

Psychiatry Investig. 2018 Apr;15(4):424-427. doi: 10.30773/pi.2016.10.25. Epub 2018 Mar 30.

DOI:10.30773/pi.2016.10.25
PMID:29593204
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5912487/
Abstract

Modafinil is generally known as a drug with low addiction potential. There are few case reports in the literature demonstrating that Modafinil, stated being capable of diminishing symptoms of attention deficit/hyperactivity disorder (ADHD), causes addiction. In the present article a Modafinil addicted ADHD case, consuming usurious doses (5,000 mg/per day) of Modafinil is presented. The case presented to our psychiatry outpatient clinic due to: requirement of in taking high dose Modafinil in order to achieve the initial effects, difficulty in obtaining the drug, irritability, anxiousness, sleep irregularities, fatigue and unpleasant vivid dreams when he did not use the drug. It was realized that the patient, himself increased doses of Modafinil incrementally, in order to keep its effects on attention symptoms at the same level. It has to be kept in mind that ADHD patients can develop Modafinil addiction. It is necessary to carry out systemic studies on this subject.

摘要

莫达非尼通常被认为是一种成瘾潜力较低的药物。文献中很少有病例报告表明,据称能够减轻注意力缺陷多动障碍(ADHD)症状的莫达非尼会导致成瘾。在本文中,介绍了一例对莫达非尼成瘾的ADHD病例,该患者服用了超高剂量(每天5000毫克)的莫达非尼。该病例因以下原因前来我们的精神科门诊:为了达到初始效果需要服用高剂量莫达非尼、获取药物困难、易怒、焦虑、睡眠不规律、疲劳以及不服用药物时出现不愉快的生动梦境。经了解,患者为了使药物对注意力症状的效果保持在同一水平,自行逐渐增加莫达非尼的剂量。必须牢记,ADHD患者可能会对莫达非尼产生成瘾。有必要针对这一主题开展系统性研究。

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Use of modafinil for the treatment of attention deficit/hyperactivity disorder.使用莫达非尼治疗注意力缺陷/多动障碍。
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Participation of Dopamine D1 and D2 Receptors in the Rapid-Onset Behavioral Sensitization to Modafinil.多巴胺D1和D2受体参与对莫达非尼的快速行为敏化作用。
Front Pharmacol. 2019 Mar 11;10:211. doi: 10.3389/fphar.2019.00211. eCollection 2019.

本文引用的文献

1
A rare case modafinil dependence.一例罕见的莫达非尼依赖病例。
J Pharmacol Pharmacother. 2015 Jan-Mar;6(1):49-50. doi: 10.4103/0976-500X.149149.
2
Compulsive modafinil use in a patient with a history of alcohol use disorder.一名有酒精使用障碍病史的患者强迫性使用莫达非尼。
Gen Hosp Psychiatry. 2015 Mar-Apr;37(2):e7-8. doi: 10.1016/j.genhosppsych.2015.01.001. Epub 2015 Jan 14.
3
In vivo activity of modafinil on dopamine transporter measured with positron emission tomography and [¹⁸F]FE-PE2I.使用正电子发射断层扫描和[¹⁸F]FE-PE2I测量莫达非尼对多巴胺转运体的体内活性。
Int J Neuropsychopharmacol. 2014 May;17(5):697-703. doi: 10.1017/S1461145713001612. Epub 2014 Jan 22.
4
Modafinil as a catecholaminergic agent: empirical evidence and unanswered questions.莫达非尼作为一种儿茶酚胺能药物:实证证据与未解决的问题。
Front Neurol. 2013 Oct 7;4:139. doi: 10.3389/fneur.2013.00139.
5
The neurobiology of modafinil as an enhancer of cognitive performance and a potential treatment for substance use disorders.莫达非尼的神经生物学:作为认知表现增强剂和物质使用障碍的潜在治疗方法。
Psychopharmacology (Berl). 2013 Oct;229(3):415-34. doi: 10.1007/s00213-013-3232-4. Epub 2013 Aug 10.
6
Dependence on supratherapeutic doses of modafinil: a case report.对莫达非尼超治疗剂量的依赖:一例报告。
Prim Care Companion CNS Disord. 2012;14(5). doi: 10.4088/PCC.11l01333. Epub 2012 Oct 18.
7
Modafinil modulates resting-state functional network connectivity and cognitive control in alcohol-dependent patients.莫达非尼调节酒精依赖患者静息状态功能网络连接和认知控制。
Biol Psychiatry. 2013 Apr 15;73(8):789-95. doi: 10.1016/j.biopsych.2012.12.025. Epub 2013 Feb 9.
8
Practical use and risk of modafinil, a novel waking drug.新型促醒药物莫达非尼的实际应用与风险
Environ Health Toxicol. 2012;27:e2012007. doi: 10.5620/eht.2012.27.e2012007. Epub 2012 Feb 22.
9
The atypical stimulant and nootropic modafinil interacts with the dopamine transporter in a different manner than classical cocaine-like inhibitors.非典型兴奋剂和认知增强剂莫达非尼与多巴胺转运体的相互作用方式不同于经典的可卡因样抑制剂。
PLoS One. 2011;6(10):e25790. doi: 10.1371/journal.pone.0025790. Epub 2011 Oct 17.
10
Modafinil for the treatment of cocaine dependence.莫达非尼用于治疗可卡因成瘾。
Drug Alcohol Depend. 2009 Sep 1;104(1-2):133-9. doi: 10.1016/j.drugalcdep.2009.04.015. Epub 2009 Jun 26.