• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
A rare case modafinil dependence.一例罕见的莫达非尼依赖病例。
J Pharmacol Pharmacother. 2015 Jan-Mar;6(1):49-50. doi: 10.4103/0976-500X.149149.
2
Modafinil alone and in combination with low dose amphetamine does not establish conditioned place preference in male Sprague-Dawley rats.莫达非尼单独使用和与低剂量安非他命联合使用均不能在雄性 Sprague-Dawley 大鼠中建立条件性位置偏爱。
Exp Clin Psychopharmacol. 2013 Jun;21(3):252-8. doi: 10.1037/a0031832. Epub 2013 May 6.
3
Modafinil : A Review of its Pharmacology and Clinical Efficacy in the Management of Narcolepsy.莫达非尼：在治疗嗜睡症中的药理学和临床疗效评价。
CNS Drugs. 1998 Apr;9(4):311-24. doi: 10.2165/00023210-199809040-00006.
4
Effects of modafinil and R-modafinil on brain stimulation reward thresholds: implications for their use in the treatment of psychostimulant dependence.莫达非尼和R-莫达非尼对脑刺激奖赏阈值的影响：对其用于治疗精神兴奋剂依赖的启示。
J Drug Alcohol Res. 2015 Dec;4. doi: 10.4303/jdar/235958. Epub 2015 Dec 29.
5
Pharmacokinetic and pharmacodynamic of the cognitive enhancer modafinil: Relevant clinical and forensic aspects.认知增强剂莫达非尼的药代动力学和药效学：相关临床和法医方面。
Subst Abus. 2020;41(2):155-173. doi: 10.1080/08897077.2019.1700584. Epub 2020 Jan 17.
6
Modafinil Dependence and Hypersexuality: A Case Report and Review of the Evidence.莫达非尼成瘾与性欲亢进：一例报告及证据综述
Clin Psychopharmacol Neurosci. 2016 Nov 30;14(4):402-404. doi: 10.9758/cpn.2016.14.4.402.
7
Modafinil: a second look. Confirmed efficacy in narcolepsy.莫达非尼：再审视。对发作性睡病疗效确凿。
Prescrire Int. 1999 Feb;8(39):5-7.
8
A systematic review of modafinil: Potential clinical uses and mechanisms of action.莫达非尼的系统评价：潜在临床用途及作用机制
J Clin Psychiatry. 2006 Apr;67(4):554-66. doi: 10.4088/jcp.v67n0406.
9
Modafinil evokes striatal [(3)H]dopamine release and alters the subjective properties of stimulants.莫达非尼可引起纹状体[³H]多巴胺释放，并改变兴奋剂的主观特性。
Eur J Pharmacol. 2007 Jul 30;568(1-3):112-23. doi: 10.1016/j.ejphar.2007.03.044. Epub 2007 Apr 5.
10
Combined effects of modafinil and d-amphetamine in male Sprague-Dawley rats trained to discriminate d-amphetamine.莫达非尼和苯丙胺联合作用于训练用于区分苯丙胺的雄性 Sprague-Dawley 大鼠。
Pharmacol Biochem Behav. 2013 Sep;110:208-15. doi: 10.1016/j.pbb.2013.07.011. Epub 2013 Jul 21.

引用本文的文献

1
Development of Modafinil Dependence Following Self-medication for Sexual Dysfunction: A Case Series.自我用药治疗性功能障碍后出现莫达非尼依赖：病例系列报告
Indian J Psychol Med. 2025 Mar;47(2):190-192. doi: 10.1177/02537176231200185. Epub 2023 Dec 7.
2
The Issue of "Smart Drugs" on the Example of Modafinil: Toxicological Analysis of Evidences and Biological Samples.以莫达非尼为例谈“聪明药”问题：证据及生物样本的毒理学分析
J Xenobiot. 2025 Jan 17;15(1):15. doi: 10.3390/jox15010015.
3
Modafinil, an atypical CNS stimulant?莫达非尼，一种非典型的中枢神经系统兴奋剂？
Adv Pharmacol. 2024;99:287-326. doi: 10.1016/bs.apha.2023.10.006. Epub 2023 Nov 22.
4
An FSCV Study on the Effects of Targeted Typical and Atypical DAT Inhibition on Dopamine Dynamics in the Nucleus Accumbens Shell of Male and Female Mice.一项 FSCV 研究探讨了靶向典型和非典型 DAT 抑制对雄性和雌性小鼠伏隔核壳多巴胺动力学的影响。
ACS Chem Neurosci. 2023 Aug 2;14(15):2802-2810. doi: 10.1021/acschemneuro.3c00354. Epub 2023 Jul 19.
5
Are There Prevalent Sex Differences in Psychostimulant Use Disorder? A Focus on the Potential Therapeutic Efficacy of Atypical Dopamine Uptake Inhibitors.是否存在普遍的性别的精神兴奋剂使用障碍差异？关注非典型多巴胺摄取抑制剂的潜在治疗效果。
Molecules. 2023 Jul 7;28(13):5270. doi: 10.3390/molecules28135270.
6
A rare case of modafinil dependence presenting as sleep disorder.一例以睡眠障碍为表现的莫达非尼依赖罕见病例。
Ind Psychiatry J. 2021 Oct;30(Suppl 1):S354-S355. doi: 10.4103/0972-6748.328856. Epub 2021 Oct 22.
7
Psychostimulant Use Disorder, an Unmet Therapeutic Goal: Can Modafinil Narrow the Gap?精神兴奋剂使用障碍，一个未实现的治疗目标：莫达非尼能缩小差距吗？
Front Neurosci. 2021 May 26;15:656475. doi: 10.3389/fnins.2021.656475. eCollection 2021.
8
The Use and Impact of Cognitive Enhancers among University Students: A Systematic Review.大学生中认知增强剂的使用与影响：一项系统综述
Brain Sci. 2021 Mar 10;11(3):355. doi: 10.3390/brainsci11030355.
9
Modafinil and its structural analogs as atypical dopamine uptake inhibitors and potential medications for psychostimulant use disorder.莫达非尼及其结构类似物作为非典型多巴胺摄取抑制剂和潜在的精神兴奋剂使用障碍治疗药物。
Curr Opin Pharmacol. 2021 Feb;56:13-21. doi: 10.1016/j.coph.2020.07.007. Epub 2020 Sep 11.
10
A review on modafinil: the characteristics, function, and use in critical care.一篇关于莫达非尼的综述：特性、功能及在重症监护中的应用
J Drug Assess. 2020 Apr 4;9(1):82-86. doi: 10.1080/21556660.2020.1745209. eCollection 2020.

本文引用的文献

1
Dependence on supratherapeutic doses of modafinil: a case report.对莫达非尼超治疗剂量的依赖：一例报告。
Prim Care Companion CNS Disord. 2012;14(5). doi: 10.4088/PCC.11l01333. Epub 2012 Oct 18.
2
A retrospective review of supratherapeutic modafinil exposures.对超治疗剂量莫达非尼暴露的回顾性审查。
J Med Toxicol. 2010 Sep;6(3):307-10. doi: 10.1007/s13181-010-0017-6.
3
Effects of modafinil on dopamine and dopamine transporters in the male human brain: clinical implications.莫达非尼对男性人脑多巴胺及多巴胺转运体的影响：临床意义
JAMA. 2009 Mar 18;301(11):1148-54. doi: 10.1001/jama.2009.351.
4
Toxicity from modafinil ingestion.莫达非尼摄入导致的毒性反应。
Clin Toxicol (Phila). 2009 Feb;47(2):153-6. doi: 10.1080/15563650802175595.
5
Psychosis associated with modafinil and shift work.与莫达非尼和轮班工作相关的精神病
Am J Psychiatry. 2005 Oct;162(10):1983. doi: 10.1176/appi.ajp.162.10.1983.
6
Modafinil: preclinical, clinical, and post-marketing surveillance--a review of abuse liability issues.莫达非尼：临床前、临床及上市后监测——滥用倾向问题综述
Ann Clin Psychiatry. 2004 Apr-Jun;16(2):101-9. doi: 10.1080/10401230490453743.

一例罕见的莫达非尼依赖病例。

A rare case modafinil dependence.

作者信息

Krishnan Raman, Chary Krishnan Vengadaragava

机构信息

Department of Psychiatry, Saveetha Medical College, Chennai, Tamil Nadu, India.

Department of Pharmacology, Saveetha Medical College, Chennai, Tamil Nadu, India.

出版信息

J Pharmacol Pharmacother. 2015 Jan-Mar;6(1):49-50. doi: 10.4103/0976-500X.149149.

DOI:10.4103/0976-500X.149149
PMID:25709356
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4319252/
Abstract

Modafinil, a non-amphetamine psychostimulant, is indicated for narcolepsy, shift work sleep disorder and severe obstructive sleep apnea syndrome. Modafinil is prescribed at the dose of 100 mg once in a day or as two doses, 12 h apart in a day. It has also been found that it reduces cocaine dependence and withdrawal phenomenon. Modafinil is claimed to have very low liability for abuse and dependence. Here we report a rare case of modafinil dependence.

摘要

莫达非尼是一种非苯丙胺类精神兴奋剂，适用于发作性睡病、倒班工作睡眠障碍和严重阻塞性睡眠呼吸暂停综合征。莫达非尼的处方剂量为每日一次100毫克，或分两次服用，每次间隔12小时。人们还发现它能降低对可卡因的依赖性和戒断现象。据称，莫达非尼的滥用和依赖可能性非常低。在此，我们报告一例罕见的莫达非尼依赖病例。