Laboratory of Nanomedicine, School of Physics and Materials Science, Thapar University, Patiala, Punjab, India.
Int J Nanomedicine. 2018 Mar 15;13(T-NANO 2014 Abstracts):3-6. doi: 10.2147/IJN.S124698. eCollection 2018.
Antimicrobial characteristics of metals reveal that Ag despite its economic constraints remains the most popular antibiotic agent. Antimicrobial characteristics of copper nanoparticles (CNPs) are not well understood. To our knowledge, no systematic comparative study on microbial properties of silver nanoparticles (SNPs) and CNPs exists. In this article, a comparative study on microbial properties of engineered metal nanoantibiotics against clinically important strains has been attempted. Our results indicate that biocidal activities of CNPs are better than SNPs. Minimum inhibitory concentration (MIC) values of CNPs are 10 times lower than the corresponding MICs of SNPs. These improved biocidal activities of CNPs would make it affordable and potent nontraditional antibiotics against which microbes are least susceptible to develop any drug resistance.
金属的抗菌特性表明，尽管银受到经济限制，但它仍然是最受欢迎的抗生素。铜纳米粒子（CNPs）的抗菌特性尚未得到很好的理解。据我们所知，目前还没有关于银纳米粒子（SNPs）和 CNPs 微生物特性的系统比较研究。在本文中，我们尝试对工程金属纳米抗生素针对临床重要菌株的微生物特性进行了比较研究。我们的结果表明，CNPs 的杀菌活性优于 SNPs。CNPs 的最小抑菌浓度（MIC）值比相应的 SNPs 的 MIC 值低 10 倍。CNPs 的这些增强的杀菌活性使其成为负担得起的、有效的非传统抗生素，微生物对其产生耐药性的可能性最小。
