The iThree Institute, University of Technology Sydney , Sydney, NSW 2007, Australia.
Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet , 17177 Stockholm, Sweden.
ACS Nano. 2017 Apr 25;11(4):3438-3445. doi: 10.1021/acsnano.7b01166. Epub 2017 Mar 24.
In this era of increasing antibiotic resistance, the use of alternative antimicrobials such as silver has become more widespread. Superior antimicrobial activity has been provided through fabrication of silver nanoparticles or nanosilver (NAg), which imparts cytotoxic actions distinct from those of bulk silver. In the wake of the recent discoveries of bacterial resistance to NAg and its rising incorporation in medical and consumer goods such as wound dressings and dietary supplements, we argue that there is an urgent need to monitor the prevalence and spread of NAg microbial resistance. In this Perspective, we describe how the use of NAg in commercially available products facilitates prolonged microorganism exposure to bioavailable silver, which underpins the development of resistance. Furthermore, we advocate for a judicial approach toward NAg use in order to preserve its efficacy and to avoid environmental disruption.
在抗生素耐药性日益严重的时代，人们越来越多地使用银等替代抗菌药物。通过制造纳米银（NAg）或银纳米粒子，提供了优于普通银的抗菌活性，其细胞毒性作用与普通银不同。最近发现细菌对 NAg 的耐药性以及 NAg 越来越多地被应用于医疗和消费品，如伤口敷料和膳食补充剂，鉴于此，我们认为迫切需要监测 NAg 微生物耐药性的流行和传播。在本观点文章中，我们描述了商业上可获得的产品中 NAg 的使用如何使微生物长时间接触生物可利用的银，这是耐药性发展的基础。此外，我们提倡对 NAg 的使用采取审慎的态度，以保持其疗效并避免对环境造成破坏。
